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Arterial NALCN Knockdown Ameliorates Mineralocorticoid-Induced Hypertension and Arterial Overcontractility.

作者信息

Lee Hyeryeong, Park Solah, Sung Dong Jun, An Jin Ryeol, Seo Mi Seon, Noh Hyun Ju, You Jueng Soo, Kim Sung Hea, Cho Hana, Kim Bokyung, Park Sang Woong, Bae Young Min

机构信息

Department of Physiology, Institute of Functional Genomics and Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, Republic of Korea (H.L., S.P., J.R.A., M.S.S., H.J.N., B.K., Y.M.B.).

Department of Sport and Health Studies, College of Biomedical and Health Science (D.J.S.), Konkuk University, Chungju, Republic of Korea.

出版信息

Circ Res. 2025 Jan 31;136(3):321-324. doi: 10.1161/CIRCRESAHA.124.325058. Epub 2025 Jan 10.

DOI:10.1161/CIRCRESAHA.124.325058
PMID:39791272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11781544/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f5/11781544/b16f210a078d/res-136-321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f5/11781544/b16f210a078d/res-136-321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f5/11781544/b16f210a078d/res-136-321-g001.jpg

相似文献

1
Arterial NALCN Knockdown Ameliorates Mineralocorticoid-Induced Hypertension and Arterial Overcontractility.动脉NALCN基因敲低可改善盐皮质激素诱导的高血压和动脉过度收缩。
Circ Res. 2025 Jan 31;136(3):321-324. doi: 10.1161/CIRCRESAHA.124.325058. Epub 2025 Jan 10.
2
Forms of mineralocorticoid hypertension.盐皮质激素性高血压的类型
Vitam Horm. 2003;66:113-56. doi: 10.1016/s0083-6729(03)01004-5.
3
[Mineralocorticoid-induced hypertension].[盐皮质激素性高血压]
Med Klin (Munich). 1997 May 15;92(5):273-8. doi: 10.1007/BF03045082.
4
Studies on the mechanism of mineralocorticoid-induced hypertension: evidence for the presence of an in-situ mechanism in the arterial wall for a direct action of mineralocorticoids.盐皮质激素诱导高血压机制的研究：盐皮质激素直接作用于动脉壁存在原位机制的证据。
Clin Biochem. 1981 Oct;14(5):282-93. doi: 10.1016/s0009-9120(81)91012-2.
5
Mineralocorticoid-induced sodium appetite and renal salt retention: evidence for common signaling and effector mechanisms.盐皮质激素诱导的钠食欲和肾盐潴留：共同信号传导和效应机制的证据。
Nephron Physiol. 2014;128(1-2):8-16. doi: 10.1159/000368264. Epub 2014 Nov 6.
6
Arterial steroid receptors and their putative role in the mechanism of hypertension.动脉甾体受体及其在高血压发病机制中的假定作用。
J Steroid Biochem. 1983 Jul;19(1A):333-44.
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Body fluid and electrolyte composition in arterial hypertension. II. Studies in mineralocorticoid hypertension.动脉高血压中的体液与电解质组成。II. 盐皮质激素性高血压的研究
J Clin Invest. 1961 Feb;40(2):416-22. doi: 10.1172/JCI104269.
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5 alpha-Dihydro-11-deoxycorticosterone as a mineralocorticoid agonist and antagonist: evidence for a weak mineralocorticoid as an antagonist of potent mineralocorticoids.5α-二氢-11-脱氧皮质酮作为盐皮质激素激动剂和拮抗剂：弱盐皮质激素作为强效盐皮质激素拮抗剂的证据。
J Steroid Biochem Mol Biol. 1993 Apr;45(4):235-8. doi: 10.1016/0960-0760(93)90337-v.
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Effect of central amiloride infusion on mineralocorticoid hypertension.
Am J Physiol. 1994 Nov;267(5 Pt 1):E754-8. doi: 10.1152/ajpendo.1994.267.5.E754.
10
Are there unknown mineralocorticoids in low-renin essential hypertension?低肾素性原发性高血压中是否存在未知的盐皮质激素？
Mayo Clin Proc. 1977 May;52(5):329-33.

本文引用的文献

1
Receptor-specific contributions of caveolae, PKC, and Src tyrosine kinase to serotonergic and adrenergic regulation of Kv channels and vasoconstriction.缝隙连接、蛋白激酶 C 和 Src 酪氨酸激酶对 K+通道和血管收缩的 5-羟色胺能和肾上腺素能调节的受体特异性贡献。
Life Sci. 2023 Sep 1;328:121903. doi: 10.1016/j.lfs.2023.121903. Epub 2023 Jun 30.
2
Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload-Induced Heart Failure.平滑肌中的盐皮质激素受体有助于压力超负荷诱导的心力衰竭。
Circ Heart Fail. 2021 Feb;14(2):e007279. doi: 10.1161/CIRCHEARTFAILURE.120.007279. Epub 2021 Feb 1.
3
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
肽类神经递质激活NALCN和UNC-80的阳离子通道复合体。
Nature. 2009 Feb 5;457(7230):741-4. doi: 10.1038/nature07579. Epub 2008 Dec 17.
4
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.丝裂原活化蛋白激酶导致高血压大鼠主动脉平滑肌基础张力升高。
Eur J Pharmacol. 2005 May 9;514(2-3):209-15. doi: 10.1016/j.ejphar.2005.03.030.
5
Contribution of Ca2+-activated K+ channels and non-selective cation channels to membrane potential of pulmonary arterial smooth muscle cells of the rabbit.钙激活钾通道和非选择性阳离子通道对兔肺动脉平滑肌细胞膜电位的作用
J Physiol. 1999 Feb 1;514 ( Pt 3)(Pt 3):747-58. doi: 10.1111/j.1469-7793.1999.747ad.x.