Oakley David, Joffe David, Palermo Francis, Spada Marta, Yathiraj Sanjay
WAVi Research, Boulder, CO, USA.
University of Colorado School of Medicine, Aurora, CO, USA.
Clin EEG Neurosci. 2025 Jan 10:15500594241310533. doi: 10.1177/15500594241310533.
Evoked potential metrics extracted from an EEG exam can provide novel sources of information regarding brain function. While the P300 occurring around 300 ms post-stimulus has been extensively investigated in relation to mild cognitive impairment (MCI), with decreased amplitude and increased latency, the P200 response has not, particularly in an oddball-stimulus paradigm. This study compares the auditory P200 amplitudes between MCI (28 patients aged 74(8)) and non-MCI, (35 aged 72(4)). Data were collected in routine clinical evaluations where EEG with audio oddball ERPs were measured as part of a health screening exam from 2 clinics serving MCI patients and one clinic serving a non-MCI population as part of a wellness/preventative care program. We also investigated the disease course for 3 patients as case studies. The results revealed the P200 amplitudes to be significantly increased in the MCI compared to the non-MCI groups, alongside the expected reduction in P300, Trail Making, and reaction time. Moreover, the ratio of P200-to-P300 was also increased in the MCI groups even in cases where the P300 was strong. This trend continued for patients who were tracked from early-to-later stages in the case studies. While the pathophysiology of the P200 response in a 2-tone auditory oddball protocol is not well understood, this measure may help indicate signs of early MCI, particularly in cases where the P300 is still strong.
从脑电图检查中提取的诱发电位指标可以提供有关脑功能的新信息来源。虽然刺激后约300毫秒出现的P300已经针对轻度认知障碍（MCI）进行了广泛研究，其表现为振幅降低和潜伏期延长，但P200反应尚未得到充分研究，尤其是在奇偶数刺激范式中。本研究比较了MCI患者（28例，年龄74（8）岁）和非MCI患者（35例，年龄72（4）岁）之间的听觉P200振幅。数据收集于常规临床评估中，在为MCI患者服务的2家诊所和为非MCI人群服务的1家诊所进行的健康筛查检查中，将脑电图与音频奇偶数事件相关电位测量作为一部分。我们还以3例患者作为案例研究调查了疾病进程。结果显示，与非MCI组相比，MCI组的P200振幅显著增加，同时P300、连线测验和反应时间也如预期那样降低。此外，即使在P300较强的情况下，MCI组中P200与P300的比值也有所增加。在案例研究中，从早期到晚期进行追踪的患者也呈现出这种趋势。虽然在双音听觉奇偶数协议中P200反应的病理生理学尚未完全了解，但这一指标可能有助于指示早期MCI的迹象，特别是在P300仍然较强的情况下。
