Pax inhibition: stressing proximal tubule for successful repair.
作者信息
Kitai Hiroki, Mulcrone Devin, Souma Tomokazu
机构信息
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States.
Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina, United States.
出版信息
Am J Physiol Renal Physiol. 2025 Feb 1;328(2):F270-F271. doi: 10.1152/ajprenal.00368.2024. Epub 2025 Jan 10.
Abstract
摘要
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本文引用的文献
1
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.Pax蛋白在近端肾小管存活及对缺血性损伤的反应中介导节段特异性功能。
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F95-F106. doi: 10.1152/ajprenal.00289.2024. Epub 2024 Dec 2.
2
Gene regulation in regeneration after acute kidney injury.急性肾损伤后再生中的基因调控。
J Biol Chem. 2024 Aug;300(8):107520. doi: 10.1016/j.jbc.2024.107520. Epub 2024 Jun 29.
3
Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.近端肾小管中 Pax 蛋白耗竭会触发对急性缺血性肾损伤的抵抗的保守机制，从而防止向慢性肾脏病的转变。
Kidney Int. 2024 Feb;105(2):312-327. doi: 10.1016/j.kint.2023.10.022. Epub 2023 Nov 17.
4
Identifying Common Molecular Mechanisms in Experimental and Human Acute Kidney Injury.鉴定实验性和人类急性肾损伤中的常见分子机制。
Semin Nephrol. 2022 May;42(3):151286. doi: 10.1016/j.semnephrol.2022.10.012. Epub 2022 Nov 17.
5
Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury.周期素依赖性激酶 4 相关的肾小管上皮细胞增殖受肾缺血再灌注损伤中配对盒基因 2 的调节。
Kidney Int. 2022 Jul;102(1):45-57. doi: 10.1016/j.kint.2022.03.022. Epub 2022 Apr 25.
6
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.鉴定抑制靶基因表达和癌细胞增殖的 Pax 蛋白抑制剂。
Cell Chem Biol. 2022 Mar 17;29(3):412-422.e4. doi: 10.1016/j.chembiol.2021.11.003. Epub 2021 Nov 24.
7
Regrow or Repair: An Update on Potential Regenerative Therapies for the Kidney.再生还是修复：肾脏潜在再生疗法的最新进展。
J Am Soc Nephrol. 2022 Jan;33(1):15-32. doi: 10.1681/ASN.2021081073. Epub 2021 Nov 17.
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Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.铁死亡应激促进适应性不良的肾脏修复过程中促炎近端肾小管细胞的积累。
Elife. 2021 Jul 19;10:e68603. doi: 10.7554/eLife.68603.
9
PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma.PAX8 通过肾细胞癌中的增强子元件激活代谢基因。
Nat Commun. 2019 Aug 20;10(1):3739. doi: 10.1038/s41467-019-11672-1.
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Are Pax proteins potential therapeutic targets in kidney disease and cancer?Pax 蛋白是否可能成为肾脏疾病和癌症的治疗靶点？
Kidney Int. 2018 Aug;94(2):259-267. doi: 10.1016/j.kint.2018.01.025. Epub 2018 Apr 21.
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