Luo Miao, Shang Luorui, Xie Jiao, Zhou Tao, He Chengyi, Fisher David, Pronyuk Khrystyna, Musabaev Erkin, Hien Nguyen Thi Thu, Wang Huan, Zhao Lei
Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 10. doi: 10.1007/s00210-024-03758-5.
Emodin, as a natural active ingredient, has shown great application potential in the fields of medicine, food and cosmetics due to its unique pharmacological effects, such as anti-inflammatory, antioxidant, anti-cancer, etc. In recent years, with the development of science and technology and the increase of people's demand for natural medicine, emodin research has been paid more and more attention by the global scientific research community. The bibliometric analysis of emodin and the construction of knowledge map are still blank. We searched the publications of emodin related studies in the Web of Science Core Collection (WoSCC) database from 2004 to 2024 and conducted a bibliometric analysis. Data processing was done using the R packages Bibliometrix, VOSviewer and CiteSpace. The consensus identified 4,125 emodin related articles from multiple countries, with China being the main contributor. The number of publications in this field is increasing year by year. China Medical University, the Chinese Academy of Sciences, and Nanjing University of Traditional Chinese Medicine are all prominent research institutions in this field. The Journal of ethnopharmacology published the most articles on the subject. The total number of authors of these articles has reached 14,991, among which Yi Wang is the author with the most output and Xiaoxv Dong is the author with the most cited times. "emodin", "apoptosis", and "liver injury" were the main research focuses. Topics such as "pharmacology", "photodynamic therapy", "advancing drug discovery" and "gallbladder cancer cell" may represent emerging areas of research in medicine. The results of this study help to identify the latest research frontiers and hot topics, and provide a valuable reference for the study of emodin family.
大黄素作为一种天然活性成分，因其具有抗炎、抗氧化、抗癌等独特药理作用，在医药、食品和化妆品领域展现出巨大的应用潜力。近年来，随着科技的发展以及人们对天然药物需求的增加，大黄素的研究越来越受到全球科研界的关注。然而，大黄素的文献计量分析及知识图谱构建尚属空白。我们检索了2004年至2024年Web of Science核心合集（WoSCC）数据库中大黄素相关研究的出版物，并进行了文献计量分析。数据处理使用了R包Bibliometrix、VOSviewer和CiteSpace。研究共识别出4125篇来自多个国家的大黄素相关文章，中国是主要贡献者。该领域的出版物数量逐年增加。中国医科大学、中国科学院和南京中医药大学都是该领域的杰出研究机构。《民族药理学杂志》发表的相关文章最多。这些文章的作者总数达14991人，其中王毅是发文量最多的作者，董晓旭是被引次数最多的作者。“大黄素”“细胞凋亡”和“肝损伤”是主要研究重点。“药理学”“光动力疗法”“推进药物发现”和“胆囊癌细胞”等主题可能代表了医学领域新兴的研究方向。本研究结果有助于识别最新的研究前沿和热点话题，为大黄素家族的研究提供有价值的参考。
