Durdu Bulent, Durdu Yasemin, Guler Eray Metin, Kocyigit Abdurrahim, Okay Gulay
Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Türkiye.
Hamidiye Vocational School of Health Services, University of Health Sciences Türkiye, Istanbul, Türkiye.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 10. doi: 10.1007/s00210-024-03772-7.
Colistin is used as a last-line treatment for multidrug-resistant gram-negative bacilli. Neurotoxicity limits clinic use of colistin. The use of colistin causes oxidative stress and inflammation. The antioxidant activities of dexpanthenol and thymoquinone are well known. The aim of this research was to investigate and compare the efficacy of dexpanthenol and thymoquinone in alleviating neurotoxicity in rats exposed to colistin therapy. The present study investigated inflammation biomarkers using enzyme-linked immunosorbent assay kits, whereas oxidative stress biomarkers were assessed using several photometric techniques. Serum and brain tissue samples were collected from rats with colistin neurotoxicity following treatment with dexpanthenol and thymoquinone. The administration of dexpanthenol markedly ameliorated colistin-induced oxidative stress indicators (except serum disulfide levels) and inflammatory biomarkers in rats. The effectiveness of thymoquinone exhibited a somewhat restricted scope. Thymoquinone demonstrated a notable enhancement in oxidative stress and inflammatory indicators in rats treated with colistin, except for serum disulfide levels, total antioxidant status (TAS), and brain tissue interleukin 6 (IL-6) levels, as these variables remained unaffected. The administration of dexpanthenol and thymoquinone has demonstrated notable neuroprotective effects in mitigating colistin-induced neurotoxicity in a rat model. A comparison of the neuroprotective properties of dexpanthenol and thymoquinone revealed that dexpanthenol had superior ameliorative effects on serum TAS and brain IL-6 levels compared to thymoquinone. The results of this study indicate that dexpanthenol may exhibit superior efficacy compared to thymoquinone in mitigating the neurotoxic adverse effects associated with colistin.
黏菌素被用作多重耐药革兰氏阴性杆菌的最后一线治疗药物。神经毒性限制了黏菌素的临床应用。黏菌素的使用会导致氧化应激和炎症。泛醇和百里醌的抗氧化活性是众所周知的。本研究的目的是调查和比较泛醇和百里醌在减轻接受黏菌素治疗的大鼠神经毒性方面的疗效。本研究使用酶联免疫吸附测定试剂盒检测炎症生物标志物，而使用几种光度技术评估氧化应激生物标志物。在用泛醇和百里醌治疗后，从患有黏菌素神经毒性的大鼠中采集血清和脑组织样本。泛醇的给药显著改善了大鼠体内黏菌素诱导的氧化应激指标（血清二硫键水平除外）和炎症生物标志物。百里醌的有效性表现出一定的局限性。百里醌在接受黏菌素治疗的大鼠中，除血清二硫键水平、总抗氧化状态（TAS）和脑组织白细胞介素6（IL-6）水平外，氧化应激和炎症指标有显著升高，因为这些变量未受影响。泛醇和百里醌的给药在减轻大鼠模型中黏菌素诱导的神经毒性方面显示出显著的神经保护作用。泛醇和百里醌神经保护特性的比较表明，与百里醌相比，泛醇对血清TAS和脑IL-6水平具有更好的改善作用。本研究结果表明，在减轻与黏菌素相关的神经毒性不良反应方面，泛醇可能比百里醌具有更好的疗效。
