Cao Kangdi, Wang Jinkun, Hou Wei
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Int J Environ Health Res. 2025 Jan 10:1-11. doi: 10.1080/09603123.2025.2451622.
Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study on data from the IEU open GWAS databases and the Breast Cancer Association Consortium to explore the potential link between air pollution (including PM, PM absorbance, PM, PM, NO, and NO) and breast cancer risk. We found that PM (odds ratio (OR) = 1.39, 95% CI: 1.07-1.80, = 0.013) and NO (OR = 1.67, 95% CI: 1.16-2.41, = 0.006) were significantly associated with elevated breast cancer risk. Furthermore, PM (OR = 2.10, 95% CI: 1.09-4.03, = 0.027) and NO (OR = 3.08, 95% CI: 1.24-7.64, = 0.015) were significantly associated with an elevated risk of luminal B/HER2-negative-like cancer. Results were stable in sensitivity analyses. This suggested that controlling air pollution could potentially reduce breast cancer risk.
先前的研究在空气污染与乳腺癌风险之间的关联上得出了不一致的结果，尚未确立明确的因果关系。为了解决这一问题，我们对IEU开放GWAS数据库和乳腺癌协会联盟的数据进行了一项两样本孟德尔随机化研究，以探索空气污染（包括PM、PM吸光度、PM、PM、NO和NO）与乳腺癌风险之间的潜在联系。我们发现，PM（优势比（OR）=1.39，95%置信区间：1.07-1.80，P=0.013）和NO（OR=1.67，95%置信区间：1.16-2.41，P=0.006）与乳腺癌风险升高显著相关。此外，PM（OR=2.10，95%置信区间：1.09-4.03，P=0.027）和NO（OR=3.08，95%置信区间：1.24-7.64，P=0.015）与管腔B/HER2阴性样癌症风险升高显著相关。敏感性分析结果稳定。这表明控制空气污染可能会降低乳腺癌风险。
