Akyuz Cim Emine Fusun, Suleyman Zeynep, Suleyman Halis, Yazici Gulce Naz, Coban Taha Abdulkadir
Department of Psychiatry, Florence Nightingale Hospital, Demiroglu Bilim University Medical Faculty, Istanbul.
Department of Nursing, Erzincan Binali Yıldırım University Faculty of Health Sciences.
Clin Neuropharmacol. 2024;47(6):213-217. doi: 10.1097/WNF.0000000000000615.
Our aim was to evaluate the comparative effects of sertraline and vortioxetine against stress-induced brain injury in rats.
The rats were assigned to a nonstress group (NSG), stress-treated control (StC), sertraline + stress (SSt), and vortioxetine + stress (VSt) groups. Sertraline and vortioxetine (10 mg/kg) were given orally by gavage to the SSt and VSt groups. One hour later, all animals (except NSG) underwent forced immobilization to establish a stress model (2 hours). The drugs were given once a day for 30 days. The animals were killed with ketamine 150 mg/kg, and tissues were removed from the cerebral cortex. One-way analysis of variance and Fisher post hoc least significant difference were conducted for the analysis.
The malondialdehyde (nmol/mL) level was 2.58 ± 0.48 in the NSG, 8.09 ± 0.57 in the StC, 3.84 ± 0.53 in the SSt, and 2.84 ± 0.20 in the VSt group (P < 0.0002). The total glutathione (mmol/g) was 7.15 ± 0.59 in the NSG, 2.41 ± 0.43 in the StC, 4.58 ± 0.26 in the SSt, and 5.98 ± 0.13 in the VSt (P < 0.0002). The total oxidant status (mmol H2O2Eq/L) level was 3.56 ± 0.20 in the NSG, 9.99 ± 0.74 in the StC, 4.97 ± 0.39 in the SSt, and 3.81 ± 0.31 in the VSt (P < 0.0002). The total antioxidant status (mmolTroloxEq/L) level was 8.65 ± 0.37 in the NSG, 3.04 ± 0.22 in the StC, 6.29 ± 0.34 in the SSt, and 7.61 ± 0.40 in the VSt (P < 0.0002). Sertraline reduced pericellular edema in astrocytes and oligodendrocytes and decreased perivascular edema, dilatation, and congestion of blood vessels, whereas these were not seen with vortioxetine.
Compared with sertraline, vortioxetine is a neuroprotective antidepressant with higher antioxidant activity and can more effectively prevent stress-induced brain tissue injury.
我们的目的是评估舍曲林和伏硫西汀对大鼠应激诱导脑损伤的比较效果。
将大鼠分为非应激组（NSG）、应激处理对照组（StC）、舍曲林+应激组（SSt）和伏硫西汀+应激组（VSt）。给SSt组和VSt组经口灌胃给予舍曲林和伏硫西汀（10mg/kg）。1小时后，所有动物（除NSG组外）接受强迫固定以建立应激模型（2小时）。每天给药1次，持续30天。用150mg/kg氯胺酮处死动物，并从大脑皮层取出组织。进行单因素方差分析和Fisher事后最小显著差异分析。
NSG组丙二醛（nmol/mL）水平为2.58±0.48，StC组为8.09±0.57，SSt组为3.84±0.53，VSt组为2.84±0.20（P<0.0002）。NSG组总谷胱甘肽（mmol/g）为7.15±0.59，StC组为2.41±0.43，SSt组为4.58±0.26，VSt组为5.98±0.13（P<0.0002）。NSG组总氧化剂状态（mmol H2O2Eq/L）水平为3.56±0.20，StC组为9.99±0.74，SSt组为4.97±0.39，VSt组为3.81±0.31（P<0.0002）。NSG组总抗氧化剂状态（mmol Trolox Eq/L）水平为8.65±0.37，StC组为3.04±0.22，SSt组为6.29±0.34，VSt组为7.61±0.40（P<0.0002）。舍曲林减轻了星形胶质细胞和少突胶质细胞的细胞周围水肿，并减少了血管周围水肿、血管扩张和充血，而伏硫西汀未观察到这些情况。
与舍曲林相比，伏硫西汀是一种具有更高抗氧化活性的神经保护性抗抑郁药，能更有效地预防应激诱导的脑组织损伤。
