Lei Chunxia, Wan Chunhui
Department of Neonatology, Wuhan Childrens Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Precision Medical Center, Wuhan Childrens Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Medicine (Baltimore). 2025 Jan 10;104(2):e41177. doi: 10.1097/MD.0000000000041177.
Understanding the differences between children with severe and non-severe types of neonatal pneumonia is crucial for clinical treatment and disease management. In this study, we retrospectively analyzed the clinical data of infants with neonatal pneumonia diagnosed as respiratory syncytial virus infection at Wuhan Children's Hospital between December 1, 2022 and November 30, 2023. Further, the recruited subjects were categorized into severe and non-severe groups based on the severity score. The collected data included general information, symptoms and signs, chest imaging results, and examination indices of the children. Finally, the data between the groups were statistically analyzed using the R software. The data showed no significant differences between the critical and noncritical groups on several dimensions. The critical group presented a longer hospital stay, a higher percentage of cesarean deliveries, as well as a significantly higher incidence of shortness of breath and cyanosis than the noncritical group. Concerning the laboratory indices, the critical group exhibited lower hemoglobin levels and a faster heart rate than the noncritical group. In terms of life-saving measures, respiratory support and drugs were more frequently required in the critical group than in the noncritical group. The utilization of some specific antibiotics was higher in the critically ill group than in the noncritically ill group. In summary, the study clarified the differences between critically and noncritically ill children with neonatal pneumonia, which could lead to the development of individualized treatment plans and improved quality of life and prognosis of children.
了解重症和非重症新生儿肺炎患儿之间的差异对于临床治疗和疾病管理至关重要。在本研究中，我们回顾性分析了2022年12月1日至2023年11月30日在武汉儿童医院被诊断为呼吸道合胞病毒感染的新生儿肺炎患儿的临床资料。此外，根据严重程度评分将招募的受试者分为重症组和非重症组。收集的数据包括患儿的一般信息、症状和体征、胸部影像学结果以及检查指标。最后，使用R软件对组间数据进行统计分析。数据显示，在几个维度上，重症组和非重症组之间没有显著差异。与非重症组相比，重症组住院时间更长，剖宫产比例更高，呼吸急促和发绀的发生率也显著更高。关于实验室指标，重症组的血红蛋白水平低于非重症组，心率更快。在救生措施方面，重症组比非重症组更频繁地需要呼吸支持和药物治疗。危重症组某些特定抗生素的使用频率高于非危重症组。总之，该研究阐明了重症和非重症新生儿肺炎患儿之间的差异，这可能有助于制定个性化治疗方案，提高患儿的生活质量和预后。
