Li Huan, Zhang Jiaxin, Ma Kewen, Ji Jie, An Chengfei, Jiang Hailun, Qu Hui, Tang Ruohan, Ren Xuesong, Du Yuzheng, Zhao Qi
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Medicine (Baltimore). 2025 Jan 10;104(2):e41075. doi: 10.1097/MD.0000000000041075.
Cerebral ischemia-reperfusion injury (CIRI) constitutes a significant etiology of exacerbated cerebral tissue damage subsequent to intravenous thrombolysis and endovascular mechanical thrombectomy in patients diagnosed with acute ischemic stroke. The treatment of CIRI has been extensively investigated through a multitude of clinical studies. Acupuncture has been demonstrated to be effective in treating CIRI. Recent 5 years studies have identified potential mechanisms of acupuncture, including regulation of autophagy, promotion of angiogenesis, inhibition of inflammation and apoptosis, modulation of cell activation, neuroplasticity regulation, and promotion of nerve regeneration. The transplantation of mesenchymal stem cells (MSCs) can effectively suppress apoptosis, modulate immune responses, and enhance the proliferation and migration of endogenous neural stem cells (NSCs), thereby compensating for the NSCs deficiency following cerebral ischemia/reperfusion injury. The combination of acupuncture and MSCs transplantation demonstrates superiority over individual treatments, significantly enhancing the survival rate of MSCs. Moreover, it facilitates the secretion of various cytokines to promote their homing and differentiation into functional neurons, thereby providing a novel approach for clinical treatment of CIRI.
脑缺血再灌注损伤（CIRI）是急性缺血性脑卒中患者静脉溶栓和血管内机械取栓后导致脑组织损伤加重的重要病因。通过大量临床研究对CIRI的治疗进行了广泛研究。针灸已被证明对治疗CIRI有效。最近5年的研究已经确定了针灸的潜在机制，包括自噬调节、血管生成促进、炎症和细胞凋亡抑制、细胞活化调节、神经可塑性调节以及神经再生促进。间充质干细胞（MSCs）移植可有效抑制细胞凋亡、调节免疫反应并增强内源性神经干细胞（NSCs）的增殖和迁移，从而弥补脑缺血/再灌注损伤后NSCs的不足。针灸与MSCs移植相结合显示出优于单一治疗的优势，显著提高了MSCs的存活率。此外，它还促进各种细胞因子的分泌，以促进其归巢并分化为功能性神经元，从而为CIRI的临床治疗提供了一种新方法。
