Wiechmann H W, Schuster P, Sturm A
Dtsch Med Wochenschr. 1985 Apr 12;110(15):588-92. doi: 10.1055/s-2008-1068869.
In 20 patients with essential arterial hypertension, grade II or III, the haemodynamic effect of a fixed combination of antihypertensive drugs (bemetizide, triamteren, bupranolol and dihydralazine) was studied by percutaneously-introduced flow-guided catheter in the pulmonary artery before, after three weeks and at the end of a six-month period of treatment; systemic arterial blood pressures were measured by the cuff method. Mean pressures, both at rest and on exercise were significantly and persistently lowered. Mean blood pressure at rest fell from 184/110 mmHg before treatment to 167/98 mmHg after three weeks, and to 158/93 mmHg after six months. The initial blood pressure on exercise was 226/129 mmHg, which fell after three weeks to 199/113 mmHg and after six months to 190/106 mmHg. At the same time, pulmonary artery pressure (as a measure of preload) fell by 23% at rest and 30% on exercise. Exercise tolerance of the patients rose by 28%. Pressure-heartrate product fell by 18%, as a pointer to an additional favourable effect on left ventricular oxygen consumption.
对20例II级或III级原发性动脉高血压患者，采用经皮插入肺动脉的血流导向导管，在治疗前、治疗三周后及六个月疗程结束时，研究了一种固定复方抗高血压药物（苄氟噻嗪、氨苯蝶啶、丁酰普洛尔和双肼屈嗪）的血流动力学效应；采用袖带法测量体循环动脉血压。静息和运动时的平均血压均显著且持续降低。静息时平均血压从治疗前的184/110 mmHg降至三周后的167/98 mmHg，六个月后降至158/93 mmHg。运动时的初始血压为226/129 mmHg，三周后降至199/113 mmHg，六个月后降至190/106 mmHg。同时，肺动脉压（作为前负荷的指标）静息时下降23%，运动时下降30%。患者的运动耐量提高了28%。压力-心率乘积下降了18%，表明对左心室氧耗有额外的有益作用。
