Riccitelli Serena, Yaakov Hadar, Heukamp Alina S, Ankri Lea, Rivlin-Etzion Michal
Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2415223122. doi: 10.1073/pnas.2415223122. Epub 2024 Dec 30.
Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large-scale recordings in the mouse retina, we show that a subset of non- direction-selective (DS) RGCs exhibit asymmetric activity, selective to motion direction, in response to a stimulus crossing an area far beyond the classic receptive field. The extraclassical response arises via inputs from an asymmetric distal zone and is enhanced by desensitization mechanisms and an inherent DS component, creating a network of neurons responding to motion toward the optic disc. Pharmacological manipulations revealed the necessity of glycinergic amacrine cells for this response. Using in vivo recordings, we identified similar extraclassical responses in lateral geniculate nucleus neurons, suggesting such non conventional DS information is transferred to downstream structures. Our results suggest a complex integration of motion direction processing across the visual field, which arises beyond the classical receptive field boundaries.
视网膜神经节细胞（RGCs）通常在其空间受限的感受野内对光刺激作出反应。通过在小鼠视网膜中进行大规模记录，我们发现一部分非方向选择性（DS）RGCs在对穿过远超经典感受野区域的刺激作出反应时，表现出对运动方向具有选择性的不对称活动。这种超经典反应通过来自不对称远端区域的输入产生，并通过脱敏机制和内在的DS成分得到增强，从而形成一个对朝向视盘运动作出反应的神经元网络。药理学操作揭示了甘氨酸能无长突细胞对于这种反应的必要性。通过体内记录，我们在外侧膝状体核神经元中鉴定出了类似的超经典反应，这表明这种非传统的DS信息会传递到下游结构。我们的结果表明，跨视野的运动方向处理存在复杂的整合，这种整合发生在经典感受野边界之外。
