骨髓间充质干细胞通过激活产热和减轻脂肪组织炎症来改善饮食诱导的肥胖。

Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.

作者信息

Wang Yanxue, Fu Jingfei, He Wanghong, Gao Yike, Du Juan, Xu Junji, Guo Lijia, Liu Yi

机构信息

Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, PR China; Department of Orthodontics (WangFuJing Campus), School of Stomatology, Capital Medical University, Beijing, PR China.

出版信息

Biochem Biophys Res Commun. 2025 Feb 2;747:151172. doi: 10.1016/j.bbrc.2024.151172. Epub 2024 Dec 20.

DOI:10.1016/j.bbrc.2024.151172

PMID:39793396

Abstract

Obesity and its related metabolic disorders seriously threaten our health and significantly reduce our life expectancy. The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs) on high-fat diet (HFD)-induced obesity mice. The results demonstrated that BMSCs significantly reduced body weight, improved glucose tolerance and insulin sensitivity in obese mice. Further analysis showed that BMSCs could promote brown adipose tissue (BAT) activity and white adipose tissue (WAT) browning by increasing the expression of mitochondrial uncouple protein 1 (UCP1). Additionally, BMSCs markedly increase mitochondrial biogenesis, activate oxidative phosphorylation (OXPHOS) in adipose tissue, further contributing to energy metabolism regulation. Moreover, BMSCs were effective in inhibiting macrophage-related inflammation in adipose tissue, thereby mitigating obesity-associated inflammatory responses. Overall, our results lay the foundation for research on the potential of BMSCs as a promising strategy in alleviating obesity and related metabolic diseases.

摘要

肥胖及其相关的代谢紊乱严重威胁我们的健康，并显著缩短我们的预期寿命。本研究的目的是探讨骨髓间充质干细胞（BMSCs）对高脂饮食（HFD）诱导的肥胖小鼠的影响。结果表明，BMSCs显著降低了肥胖小鼠的体重，改善了葡萄糖耐量和胰岛素敏感性。进一步分析表明，BMSCs可通过增加线粒体解偶联蛋白1（UCP1）的表达来促进棕色脂肪组织（BAT）活性和白色脂肪组织（WAT）褐变。此外，BMSCs显著增加线粒体生物合成，激活脂肪组织中的氧化磷酸化（OXPHOS），进一步有助于能量代谢调节。此外，BMSCs可有效抑制脂肪组织中与巨噬细胞相关的炎症，从而减轻肥胖相关的炎症反应。总体而言，我们的结果为研究BMSCs作为缓解肥胖及相关代谢疾病的一种有前景策略的潜力奠定了基础。