Lobova T G, Lichinitser M R, Dobrynin Ia V, Nikolaeva T G, Zharkov S A
Eksp Onkol. 1985;7(1):58-60.
The in vitro experiments on CaOv cells demonstrated that ribamidyl (ribavirine) (Rb) enhances the intracellular pool of pyrimidine precursors of DNA. This was the basis for studies of its modifying effect on the antitumour activity of antimetabolites. In experiments with intact hybrid mice F1 (CBA+C57B1) the five times administration of ribavirine increase sharply the toxicity of 5-FU. The data should be taken into consideration when combining Rb with antimetabolites in clinical practice.
对CaOv细胞的体外实验表明，利巴米啶（利巴韦林）（Rb）可增加DNA嘧啶前体的细胞内储备。这是研究其对抗代谢物抗肿瘤活性修饰作用的基础。在对完整的杂种小鼠F1（CBA+C57B1）进行的实验中，五次给予利巴韦林会大幅增加5-氟尿嘧啶的毒性。在临床实践中将Rb与抗代谢物联合使用时，应考虑这些数据。
