Ramakrishnan Praveen, Ramprasath Ramakrishnan, Jalaludeen Abdulkadhar Mohamed, Jayakumar R, Jolius Gimbun, Balu Ranganathan, Mohamed S B, Sridhar T M, Gunasekaran Sivagaami Sundari, Davoodbasha MubarakAli, Thajuddin Nooruddin, Gnanasekaran Lalitha, Sundaram Thanigaivel
Crescent Global Outreach Mission Research and Development, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai 620048, Tamil Nadu, India.
Abinnovus Consulting Private Limited, TBI-University of Madras, Chennai 600025, Tamil Nadu, India.
Int J Biol Macromol. 2025 Mar;296:139663. doi: 10.1016/j.ijbiomac.2025.139663. Epub 2025 Jan 8.
Tissue engineering plays a vital role in the medical field that addresses the repair, regeneration, and replacement of damaged tissues or organs. The development of drug-eluting electrospun nanofiber composed of biological macromolecules plays a key role in providing localized drug delivery and structural support. This review examines the recent development and impact of electrospun nanofibers in the field of tissue engineering and explores their potential applications. This review also investigates into the fabrication techniques of nanofibers, highlighting the use of biopolymers like collagen and chitosan, chiefly, focuses on understanding the mechanisms of drug-releasing features of these nanofibers. Studies concerning the medical applications of these nanofibers, such as wound healing, skin regeneration, bone tissue engineering, and neural repair, were also reviewed. Beyond the application in tissue regeneration, this review also explores the potential efficacy of nanofibres in cancer therapy, antibacterial activity, enzyme immobilization, and biosensing applications. This study provides an up-to-date critical insight into the applications of electrospun nanofiber application and key scalable production processes, underscoring the potential economic impacts of advanced wound care technologies. While outlining current challenges, this paper also offers future perspectives on the design, application, and potential expansion of drug-eluting electrospun fibers in medical sciences, ultimately showcasing their pivotal role in advancing therapeutic outcomes.
组织工程在解决受损组织或器官的修复、再生和替换问题的医学领域中发挥着至关重要的作用。由生物大分子组成的药物洗脱电纺纳米纤维的发展在提供局部药物递送和结构支持方面起着关键作用。本综述考察了电纺纳米纤维在组织工程领域的最新发展和影响，并探讨了它们的潜在应用。本综述还研究了纳米纤维的制造技术，强调了胶原蛋白和壳聚糖等生物聚合物的使用，主要聚焦于理解这些纳米纤维的药物释放特性机制。还综述了有关这些纳米纤维医学应用的研究，如伤口愈合、皮肤再生、骨组织工程和神经修复。除了在组织再生中的应用，本综述还探讨了纳米纤维在癌症治疗、抗菌活性、酶固定化和生物传感应用中的潜在功效。本研究对电纺纳米纤维应用及关键可扩展生产工艺的应用提供了最新的批判性见解，强调了先进伤口护理技术的潜在经济影响。在概述当前挑战的同时，本文还对药物洗脱电纺纤维在医学科学中的设计、应用和潜在扩展提供了未来展望，最终展示了它们在推进治疗效果方面的关键作用。
