Patel Dinesh K, Won So-Yeon, Jung Eunseo, Han Sung Soo
School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea.
School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea.
Int J Biol Macromol. 2025 Mar;293:139426. doi: 10.1016/j.ijbiomac.2024.139426. Epub 2025 Jan 1.
Tissue engineering offers an alternative approach to developing biological substitutes that restore, maintain, or enhance tissue functionality by integrating principles from medicine, biology, and engineering. In this context, biopolymer-based electrospun nanofibers have emerged as attractive platforms due to their superior physicochemical properties, including excellent biocompatibility, non-toxicity, and desirable biodegradability, compared to synthetic polymers. Considerable efforts have been dedicated to developing suitable substitutes for various biomedical applications, with electrospinning receiving considerable attention as a versatile technique for fabricating nanofibrous platforms. While the applications of biopolymer-based electrospun nanofibers in the biomedical field have been previously reviewed, recent advancements in the electrospinning technique and its specific applications in areas such as bone regeneration, wound healing, drug delivery, and protein/peptide delivery remain underexplored from a material science perspective. This work systematically highlights the effects of biopolymers and critical parameters, including polymer molecular weight, viscosity, applied voltage, flow rate, and tip-to-collector distance, on the resulting nanofiber properties. The selection criteria for different biopolymers tailored to desired biomedical applications are also discussed. Additionally, the challenges and limitations associated with biopolymer-based electrospun nanofibers, alongside future perspectives for advancing their biomedical applications, are rationally analyzed.
组织工程提供了一种开发生物替代品的替代方法，该方法通过整合医学、生物学和工程学原理来恢复、维持或增强组织功能。在这种背景下，基于生物聚合物的电纺纳米纤维因其优异的物理化学性质，包括与合成聚合物相比具有出色的生物相容性、无毒性和理想的生物降解性，而成为有吸引力的平台。人们已经付出了相当大的努力来开发适用于各种生物医学应用的替代品，电纺作为一种制造纳米纤维平台的通用技术受到了广泛关注。虽然之前已经对基于生物聚合物的电纺纳米纤维在生物医学领域的应用进行了综述，但从材料科学的角度来看，电纺技术的最新进展及其在骨再生、伤口愈合、药物递送和蛋白质/肽递送等领域的具体应用仍未得到充分探索。这项工作系统地突出了生物聚合物和关键参数（包括聚合物分子量、粘度、施加电压、流速和针尖到收集器的距离）对所得纳米纤维性能的影响。还讨论了针对所需生物医学应用定制的不同生物聚合物的选择标准。此外，还对基于生物聚合物的电纺纳米纤维相关的挑战和局限性以及推进其生物医学应用的未来前景进行了合理分析。
