拓展代谢功能障碍相关脂肪性肝病与癌症的研究视野。
Widening research horizons on metabolic dysfunction-associated steatotic liver disease and cancer.
作者信息
Lonardo Amedeo, Stefan Norbert, Mantovani Alessandro
机构信息
Department of Internal Medicine, Azienda Ospedaliero Universitaria of Modena (-2023), Modena, Italy.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University of Tübingen, Tübingen, Germany; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, Tübingen, Germany.
出版信息
Trends Endocrinol Metab. 2025 Jul;36(7):610-613. doi: 10.1016/j.tem.2024.12.009. Epub 2025 Jan 10.
Liver fibrosis and biological sex variably modulate the risks of hepatocellular carcinoma (HCC) and extrahepatic cancers (EHCs) arising in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we highlight how these variables may have implications in the setting of chemoprevention and precision medicine approaches in MASLD and guide additional research.
肝纤维化和生物性别对代谢功能障碍相关脂肪性肝病（MASLD）背景下发生肝细胞癌（HCC）和肝外癌症（EHCs）的风险有不同程度的调节作用。在此，我们强调这些变量如何可能对MASLD的化学预防和精准医学方法产生影响，并指导进一步的研究。
Zotero 插件