Song Jianmeng, Carmona-Torres Edgardo, Kambari Yasaman, Chavez Sofia, Ueno Fumihiko, Koizum Teruki, Amaev Aron, Abdolizadeh Ali, De Luca Vincenzo, Blumberger Daniel M, Remington Gary, Pollock Bruce, Graff-Guerrero Ariel, Gerretsen Philip
Multimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Schizophrenia (Heidelb). 2025 Jan 10;11(1):2. doi: 10.1038/s41537-024-00536-3.
Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. To date, limited studies have investigated the association between regional cerebral blood flow (CBF) and impaired insight in schizophrenia. Therefore, we sought to investigate the relationship between regional CBF, as measured by arterial spin labeling (ASL), and impaired insight in participants with schizophrenia. A total of 32 participants were included in the analysis. Impaired insight in patients with schizophrenia was measured using the VAGUS, Self-report (VAGUS-SR). Resting-state regional CBF was measured using pseudo-continuous ASL (pCASL) and extracted using SPM12 and REX toolbox. Whole brain analysis found that impaired insight was associated with higher regional CBF in the right angular gyrus, left supramarginal gyrus, and right superior frontal region when controlling for age, gender, smoking status, and illness severity. The results indicate that impaired insight in schizophrenia is related to regional CBF in frontoparietal areas. These neuroimaging findings can serve as therapeutic targets for intervention, such as with non-invasive brain stimulation.
根据疾病阶段，高达98%的精神分裂症患者存在对疾病的洞察力受损，这会导致负面的临床结果。先前的神经影像学研究表明，精神分裂症患者的洞察力受损可能与额顶叶脑区的结构和功能异常有关。迄今为止，关于区域脑血流量（CBF）与精神分裂症患者洞察力受损之间关联的研究有限。因此，我们试图研究通过动脉自旋标记（ASL）测量的区域CBF与精神分裂症参与者洞察力受损之间的关系。共有32名参与者纳入分析。使用迷走神经自我报告量表（VAGUS-SR）测量精神分裂症患者的洞察力受损情况。使用伪连续动脉自旋标记（pCASL）测量静息态区域CBF，并使用SPM12和REX工具箱进行提取。全脑分析发现，在控制年龄、性别、吸烟状况和疾病严重程度后，洞察力受损与右侧角回、左侧缘上回和右侧额上区较高的区域CBF相关。结果表明，精神分裂症患者的洞察力受损与额顶叶区域的CBF有关。这些神经影像学发现可作为干预的治疗靶点，如采用非侵入性脑刺激。
