Xu Jiashuang, Li Qiang, Gao Ziyun, Ji Pengjuan, Ji Qiqi, Song Miaojing, Chen Yian, Sun Hong, Wang Xin, Zhang Lin, Guo Leilei
School of Nursing, Jinzhou Medical University, No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province, P.R. China.
Department of Traditional Chinese Medicine and Dermatology, No. 968 Hospital of the People's Liberation Army Joint Logistics Support Force, Jinzhou, Liaoning Province, P.R. China.
BMC Cancer. 2025 Jan 10;25(1):64. doi: 10.1186/s12885-025-13468-7.
The goal of this current research was to explore the impact of cancer-related fatigue on the quality of life among patients with cancer, as well as the multiple mediating roles of psychological coherence and stigma.
This study utilized a cross-sectional design. A questionnaire was administered between November 2022 and May 2023 to 364 patients with cancer in two tertiary hospitals in Jinzhou City, Liaoning Province, China. The questionnaires included the General Information Questionnaire, Cancer-Related Fatigue Questionnaire, Psychological Coherence Scale, Stigma Scale, and Quality of Life Questionnaire. SPSS 25.0 and PROCESS 3.5 macros were used for descriptive statistics and correlation analysis of the data, as well as multiple mediation effect tests.
Cancer-related fatigue directly affects quality of life (β = -0.950, 95% CI = -1.138 to -0.763) and indirectly through three mediators: psychological coherence (β = -0.172, 12.58% of total effect), stigma (β = -0.193, 14.12% of total effect), and both psychological coherence and stigma (β = -0.052, 3.80% of total effect), totaling a 30.50% mediating effect.
Overall, psychological coherence and stigma may play an important mediating role between cancer-related fatigue and quality of life in patients with cancer. This suggests that alleviating cancer-related fatigue, while enhancing psychological coherence and reducing stigma, could be effective strategies for improving patients' quality of life. Therefore, healthcare professionals and related professionals should pay attention to and adopt effective interventions to alleviate cancer-related fatigue, enhance psychological coherence, and reduce stigma, thereby contributing to the overall well-being and quality of life of patients with cancer.
本研究旨在探讨癌症相关疲劳对癌症患者生活质量的影响，以及心理一致感和耻辱感的多重中介作用。
本研究采用横断面设计。于2022年11月至2023年5月对中国辽宁省锦州市两家三级医院的364例癌症患者进行问卷调查。问卷包括一般信息问卷、癌症相关疲劳问卷、心理一致感量表、耻辱感量表和生活质量问卷。使用SPSS 25.0和PROCESS 3.5宏对数据进行描述性统计和相关性分析，以及多重中介效应检验。
癌症相关疲劳直接影响生活质量（β = -0.950，95%CI = -1.138至-0.763），并通过三种中介间接影响：心理一致感（β = -0.172，占总效应的12.58%）、耻辱感（β = -0.193，占总效应的14.12%）以及心理一致感和耻辱感两者（β = -0.052，占总效应的3.80%），中介效应总计为30.50%。
总体而言，心理一致感和耻辱感可能在癌症患者的癌症相关疲劳和生活质量之间发挥重要的中介作用。这表明缓解癌症相关疲劳，同时增强心理一致感和减少耻辱感，可能是改善患者生活质量的有效策略。因此，医护人员及相关专业人员应关注并采取有效干预措施来缓解癌症相关疲劳、增强心理一致感和减少耻辱感，从而促进癌症患者的整体幸福感和生活质量。
