Kariksiz Mesut, Kirkik Duygu
Department of Orthopedic and traumatology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
Hamidiye Medicine Faculty, Department of Medical Biology, University of Health Sciences, Istanbul, Türkiye.
J Orthop Surg Res. 2025 Jan 10;20(1):37. doi: 10.1186/s13018-025-05467-y.
Despite their biocompatibility, metal implants are susceptible to infections, leading to implant failure and patient complications. The purpose of this study was to investigate the antibacterial potential of antibiotic-coated titanium and stainless steel implants.
The study was designed as an experimental in vitro study, and it was conducted at the Department of Immunology of the University of Health Sciences, Istanbul/ Turkiye in January and February 2024. Pieces of titanium and stainless steel were coated with gentamicin, teicoplanin, rifampicin and a combination of rifampicin and gentamicin using a dipping method. Antibacterial activity against Staphylococcus epidermidis and Staphylococcus aureus was assessed using zone of inhibition (ZOI) measurements.
Both titanium and stainless steel implants displayed significant ZOI values for all antibiotic treatments, indicating effective inhibition of bacterial growth. The combination of gentamicin and rifampicin exhibited the largest ZOI for both implants.
Antibiotic-coated titanium and stainless steel implants demonstrate promising potential for reducing implant-associated infections. Further research is needed to optimise the coating method, explore combination therapies and evaluate the long-term efficacy of this approach in clinical settings.
尽管金属植入物具有生物相容性，但它们易受感染，导致植入物失效和患者出现并发症。本研究的目的是调查抗生素涂层钛和不锈钢植入物的抗菌潜力。
本研究设计为体外实验研究，于2024年1月和2月在土耳其伊斯坦布尔健康科学大学免疫学系进行。采用浸渍法将庆大霉素、替考拉宁、利福平以及利福平和庆大霉素的组合涂覆在钛片和不锈钢片上。使用抑菌圈（ZOI）测量评估对表皮葡萄球菌和金黄色葡萄球菌的抗菌活性。
对于所有抗生素处理，钛和不锈钢植入物均显示出显著的抑菌圈值，表明对细菌生长有有效抑制。庆大霉素和利福平的组合对两种植入物均表现出最大的抑菌圈。
抗生素涂层钛和不锈钢植入物在减少植入物相关感染方面显示出有前景的潜力。需要进一步研究以优化涂层方法、探索联合治疗方案并评估该方法在临床环境中的长期疗效。
