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一名儿科患者糜烂性扁平苔藓的诊断难点

Diagnostic Difficulties of Erosive Lichen Planus in a Pediatric Patient.

作者信息

Szwed Carolyn, Gudziewski Olivia, Sar-Pomian Marta, Olszewska Malgorzata, Rudnicka Lidia, Czuwara Joanna

机构信息

Department of Dermatology, Medical University of Warsaw, 02-006 Warsaw, Poland.

出版信息

Diagnostics (Basel). 2024 Dec 27;15(1):35. doi: 10.3390/diagnostics15010035.

Abstract

Lichen planus (LP) is a chronic inflammatory disease that can present with significant morbidity, particularly in children. Erosive lichen planus (ELP), its rare destructive subtype, can be particularly difficult to diagnose and manage. We present a rare pediatric case of ELP with multisite involvement and discuss the differential diagnosis. A 12-year-old boy presented with painful erosions and ulcers on the lateral tongue and dystrophic nails. His six-year history of tongue and nail lesions prompted several comprehensive examinations. Laboratory tests did not reveal any abnormalities. Histopathological examination of the tongue lesions was representative of ELP. Line-field confocal optical coherence tomography (LC-OCT) examination of the tongue lesions showed features that strongly correlated with histopathology. The patient was later hospitalized due to dysphagia and esophageal food impaction, during which esophageal ELP was confirmed. The patient was initially managed with topical corticosteroids. He was later started on systemic therapy in the form of methotrexate and low-dose naltrexone to address his symptoms and disease presentation. This case highlights the complexities of diagnosis and management of ELP in pediatric patients. A multidisciplinary approach and regular follow-up are necessary to manage symptoms, prevent complications, and improve quality of life.

摘要

扁平苔藓(LP)是一种慢性炎症性疾病,可导致严重的发病率,尤其是在儿童中。糜烂性扁平苔藓(ELP)是其罕见的破坏性亚型,可能特别难以诊断和管理。我们报告一例罕见的多部位累及的儿童ELP病例,并讨论其鉴别诊断。一名12岁男孩出现舌外侧疼痛性糜烂和溃疡以及甲营养不良。他有6年的舌部和指甲病变病史,促使进行了多次全面检查。实验室检查未发现任何异常。舌部病变的组织病理学检查符合ELP表现。舌部病变的线场共聚焦光学相干断层扫描(LC-OCT)检查显示的特征与组织病理学密切相关。患者后来因吞咽困难和食管食物嵌塞住院,在此期间确诊为食管ELP。患者最初接受局部糖皮质激素治疗。后来开始采用甲氨蝶呤和低剂量纳曲酮进行全身治疗,以缓解其症状和疾病表现。本病例突出了儿童患者ELP诊断和管理的复杂性。采用多学科方法并定期随访对于控制症状、预防并发症和提高生活质量是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/037f/11720232/32adf3bddc0c/diagnostics-15-00035-g001.jpg

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