Alfurhud Ahmed Ata
Oral and Maxillofacial Surgery and Diagnostic Sciences Department, College of Dentistry, Jouf University, King Khalid Road, Sakaka 72388, Saudi Arabia.
Diagnostics (Basel). 2025 Jan 4;15(1):104. doi: 10.3390/diagnostics15010104.
: To discuss the prognostic outcomes, controversies and assessment of bone erosion or invasion of oral squamous cell carcinoma (OSCC). A structured literature review was conducted to critically analyse relevant evidence. The Web of Science database was searched using specific keywords aligned with the review question. After identifying initial studies, their references were also reviewed to include any additional relevant publications, ensuring a comprehensive evaluation of the available evidence. The search identified 11 relevant studies, including 5 from the initial search and 6 from reference review. The significance of bone involvement is unclear in OSCC, with varying definitions of cortical bone erosion and medullary bone infiltration contributing to conflicting results regarding the prognostic significance of bone involvement. The majority of evidence stems from retrospective cohort studies without clear study criteria and a lack of power to draw valid conclusions. There are currently a lack of high-quality studies assessing bone invasion in OSCC. While there appears to be some evidence that medullary bone infiltration is prognostic, further well-designed studies are warranted.
探讨口腔鳞状细胞癌（OSCC）骨侵蚀或侵犯的预后结果、争议及评估。进行了结构化文献综述以批判性地分析相关证据。使用与综述问题相符的特定关键词检索科学网数据库。确定初始研究后，还对其参考文献进行了审查，以纳入任何其他相关出版物，确保对现有证据进行全面评估。检索确定了11项相关研究，包括初始检索中的5项和参考文献审查中的6项。在OSCC中，骨受累的意义尚不清楚，皮质骨侵蚀和髓质骨浸润的定义各异，导致关于骨受累预后意义的结果相互矛盾。大多数证据来自回顾性队列研究，缺乏明确的研究标准且缺乏得出有效结论的能力。目前缺乏评估OSCC骨侵犯的高质量研究。虽然似乎有一些证据表明髓质骨浸润具有预后意义，但仍需要进一步设计良好的研究。
