Shah Iqbal Ali, Ishaq Shahid, Lee Shin-Da, Wu Bor-Tsang
PhD Program in Healthcare Science, China Medical University, Taichung 40402, Taiwan.
Department of Physical Therapy, China Medical University, Taichung 40402, Taiwan.
Int J Mol Sci. 2024 Dec 24;26(1):8. doi: 10.3390/ijms26010008.
A diabetic heart is characterized by fibrosis, autophagy, oxidative stress, and altered mitochondrial functions. For this review, three databases (PubMed, EMBASE, and Web of Science) were searched for articles written in English from September 2023 to April 2024. Studies that used exercise training for at least 3 weeks and which reported positive, negative, or no effects were included. The CAMARADES checklist was used to assess the quality of the included studies, and ten studies (CAMARADES scores 4-7/10) were included. Nine studies showed that exercise training improved cardiac mitochondrial oxidative phosphorylation by decreasing ROS, increasing electron transport chain activity, and enhancing the production of ATP. Eight studies indicated that exercise training ameliorated mitochondrial biogenesis by increasing the levels of AMPK, PGC-1α, Akt, Irisin, and Sirtuin-III. Moreover, four studies focused on mitochondrial dynamics and concluded that exercise training helped decrease the levels of mitochondrial fission factor and dynamin-related protein- 1. Finally, six studies revealed improvements in mitochondrial physiological characteristics such as size, potential, and permeability. Our findings demonstrate the beneficial effects of exercise training on cardiac mitochondrial function in diabetic hearts. Exercise training improves cardiac mitochondrial physiological characteristics, oxidative phosphorylation, biogenesis, and dynamics.
糖尿病心脏的特征是纤维化、自噬、氧化应激和线粒体功能改变。在本次综述中，检索了三个数据库（PubMed、EMBASE和Web of Science），以查找2023年9月至2024年4月期间用英文撰写的文章。纳入了使用运动训练至少3周且报告了阳性、阴性或无影响的研究。使用CAMARADES清单评估纳入研究的质量，共纳入了十项研究（CAMARADES评分4 - 7/10）。九项研究表明，运动训练通过降低活性氧、增加电子传递链活性和提高ATP生成来改善心脏线粒体氧化磷酸化。八项研究表明，运动训练通过增加AMPK、PGC - 1α、Akt、鸢尾素和Sirtuin - III的水平来改善线粒体生物发生。此外，四项研究关注线粒体动力学，并得出运动训练有助于降低线粒体分裂因子和动力相关蛋白 - 1水平的结论。最后，六项研究显示线粒体的大小、电位和通透性等生理特征有所改善。我们的研究结果证明了运动训练对糖尿病心脏中心脏线粒体功能具有有益作用。运动训练可改善心脏线粒体的生理特征、氧化磷酸化、生物发生和动力学。
