Sports Physiology Department, Beijing Sport University, Beijing, China.
PE Teaching and Research Office, University of International Relationship, Beijing, China.
Exp Physiol. 2024 Feb;109(2):190-201. doi: 10.1113/EP091309. Epub 2023 Oct 16.
Diabetic cardiomyopathy (DCM) is a significant cause of heart failure in patients with diabetes, and its pathogenesis is closely related to myocardial mitochondrial injury and functional disability. Studies have shown that the development of diabetic cardiomyopathy is related to disorders in mitochondrial metabolic substrates, changes in mitochondrial dynamics, an imbalance in mitochondrial Ca regulation, defects in the regulation of microRNAs, and mitochondrial oxidative stress. Physical activity may play a role in resistance to the development of diabetic cardiomyopathy by improving myocardial mitochondrial biogenesis, the level of autophagy and dynamic changes in fusion and division; enhancing the ability to cope with oxidative stress; and optimising the metabolic substrates of the myocardium. This paper puts forward a new idea for further understanding the specific mitochondrial mechanism of the occurrence and development of diabetic cardiomyopathy and clarifying the role of exercise-mediated myocardial mitochondrial changes in the prevention and treatment of diabetic cardiomyopathy. This is expected to provide a new theoretical basis for exercise to reduce diabetic cardiomyopathy symptoms.
糖尿病性心肌病（DCM）是糖尿病患者心力衰竭的重要原因，其发病机制与心肌线粒体损伤和功能障碍密切相关。研究表明，糖尿病性心肌病的发展与线粒体代谢底物的紊乱、线粒体动力学的变化、线粒体 Ca 调节失衡、miRNA 调节缺陷以及线粒体氧化应激有关。运动可能通过改善心肌线粒体生物发生、自噬水平以及融合和分裂的动态变化；增强应对氧化应激的能力；优化心肌的代谢底物，在抵抗糖尿病性心肌病的发展中发挥作用。本文提出了一个新的观点，即进一步了解糖尿病性心肌病发生和发展的具体线粒体机制，以及运动介导的心肌线粒体变化在预防和治疗糖尿病性心肌病中的作用。这有望为运动减轻糖尿病性心肌病症状提供新的理论基础。
