Nasadiuk Khrystyna, Kolanowski Tomasz, Kowalewski Cezary, Wozniak Katarzyna, Oldak Tomasz, Rozwadowska Natalia
Research and Development Department, Polski Bank Komórek Macierzystych S.A. (FamiCord Group), 00-867 Warsaw, Poland.
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.
Int J Mol Sci. 2024 Dec 29;26(1):199. doi: 10.3390/ijms26010199.
Chronic wounds and injuries remain a substantial healthcare challenge, with significant burdens on patient quality of life and healthcare resources. Mesenchymal stromal cells (MSCs) present an innovative approach to enhance tissue repair and regeneration in the context of wound healing. The intrinsic presence of MSCs in skin tissue, combined with their roles in wound repair, ease of isolation, broad secretory profile, and low immunogenicity, makes them especially promising for treating chronic wounds. This review explores the current landscape of MSC application, focusing on preclinical and clinical data across chronic wounds, diabetic ulcers, burns, non-union bone fractures, lower extremity venous ulcers, pressure ulcers, and genetic skin conditions like epidermolysis bullosa. Special emphasis is given to the mechanisms through which MSCs exert their regenerative effects, underscoring their potential in advancing wound healing therapies and supporting the broader field of regenerative medicine.
慢性伤口和损伤仍然是一个重大的医疗挑战，给患者的生活质量和医疗资源带来了沉重负担。间充质基质细胞（MSCs）为在伤口愈合过程中促进组织修复和再生提供了一种创新方法。MSCs在皮肤组织中的固有存在，加上它们在伤口修复中的作用、易于分离、广泛的分泌谱以及低免疫原性，使其在治疗慢性伤口方面特别有前景。本综述探讨了MSCs应用的当前情况，重点关注慢性伤口、糖尿病溃疡、烧伤、骨不连骨折、下肢静脉溃疡、压疮以及遗传性皮肤病如大疱性表皮松解症等方面的临床前和临床数据。特别强调了MSCs发挥其再生作用的机制，突出了它们在推进伤口愈合治疗和支持再生医学更广泛领域方面的潜力。
