Kim Jeong-Hee, Kim Hang-Keun, Son Young-Don, Kim Jong-Hoon
Biomedical Engineering Research Center, Gachon University, Incheon 21936, Republic of Korea.
Department of Biomedical Engineering, College of IT Convergence, Gachon University, Seongnam-si 13120, Republic of Korea.
Int J Mol Sci. 2024 Dec 30;26(1):252. doi: 10.3390/ijms26010252.
To elucidate the potential roles of presynaptic and postsynaptic serotonergic activity in impulsivity traits, we investigated the relationship between self-reported impulsiveness and serotonin transporter (5-HTT) and 5-HT2A receptors in healthy individuals. In this study, 26 participants completed 3-Tesla magnetic resonance imaging and positron emission tomography with [C]DASB and [C]MDL100907. To quantify 5-HTT and 5-HT2A receptor availability, the binding potential (BP) of [C]DASB and [C]MDL100907 was derived using the simplified reference tissue model with cerebellar gray matter as the reference region. The participants' impulsivity levels were assessed using the Barratt Impulsiveness Scale-11 (BIS-11). The region of interest (ROI)-based partial correlation analysis with age, sex, and temperament traits as covariates revealed a significant positive correlation between non-planning impulsiveness and [C]MDL100907 BP in the caudate (CAU) at Bonferroni-corrected < 0.0045. Non-planning impulsiveness was also positively correlated with [C]MDL100907 BP in the prefrontal cortex (PFC), ventromedial PFC, orbitofrontal cortex (OFC), insula (INS), amygdala (AMYG), putamen, ventral striatum, and thalamus, and the total score of BIS-11 was positively correlated with [C]MDL100907 BP in the OFC, INS, AMYG, and CAU at uncorrected < 0.05. Motor impulsiveness had a positive correlation with [C]DASB BP in the CAU at uncorrected < 0.05. Our results suggest that impulsivity traits, characterized by focusing on the present moment without considering future consequences, may be involved in serotonergic neurotransmission, particularly 5-HT2A receptor-mediated postsynaptic signaling in the CAU, which plays an important role in cognitive processes related to executive function, judgment of alternative outcomes, and inhibitory control.
为了阐明突触前和突触后5-羟色胺能活性在冲动特质中的潜在作用，我们研究了健康个体中自我报告的冲动性与5-羟色胺转运体（5-HTT）和5-HT2A受体之间的关系。在本研究中，26名参与者完成了3特斯拉磁共振成像以及使用[C]DASB和[C]MDL100907的正电子发射断层扫描。为了量化5-HTT和5-HT2A受体的可用性，使用以小脑灰质为参考区域的简化参考组织模型得出[C]DASB和[C]MDL100907的结合潜能（BP）。使用巴拉特冲动性量表-11（BIS-11）评估参与者的冲动水平。以年龄、性别和气质特质作为协变量的基于感兴趣区域（ROI）的偏相关分析显示，在经邦费罗尼校正P < 0.0045时，非计划性冲动与尾状核（CAU）中[C]MDL100907的BP之间存在显著正相关。非计划性冲动与前额叶皮质（PFC）、腹内侧前额叶皮质、眶额皮质（OFC）、脑岛（INS）、杏仁核（AMYG）、壳核、腹侧纹状体和丘脑的[C]MDL100907的BP也呈正相关，并且在未经校正P < 0.05时，BIS-11的总分与OFC、INS、AMYG和CAU中[C]MDL100907的BP呈正相关。运动冲动性在未经校正P < 0.05时与CAU中[C]DASB的BP呈正相关。我们的结果表明，以专注于当下而不考虑未来后果为特征的冲动特质可能与5-羟色胺能神经传递有关，特别是CAU中5-HT2A受体介导的突触后信号传导，这在与执行功能、替代结果判断和抑制控制相关的认知过程中起重要作用。
