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鼻窦和鼻腔鳞状细胞癌隐匿性淋巴结转移率是多少?系统综述。

What is the rate of occult nodal metastasis in squamous cell carcinomas of the sinonasal tract? A systematic review.

机构信息

Department of Anatomy and Surgical Anatomy, School of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.

Medical School, University of Nicosia, 2408, Nicosia, Cyprus.

出版信息

Eur Arch Otorhinolaryngol. 2024 Jul;281(7):3325-3331. doi: 10.1007/s00405-024-08481-8. Epub 2024 Feb 17.


DOI:10.1007/s00405-024-08481-8
PMID:38367074
Abstract

OBJECTIVE: The role of elective neck dissection (END) in the management of clinical N0 (cN0) squamous cell carcinomas (SCC) of the sinonasal tract is unclear. In this systematic review, we evaluate the risk of occult nodal metastasis in sinonasal SCCs with cN0M0 tumors to support clinical decision making. METHODS: A literature search was conducted in the following three electronic databases: Medline/PubMed, ScienceDirect, and Google Scholar. Articles were assessed for eligibility in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Two independent authors extracted the data. The Methodological Items for Non-Randomized Studies (MINORS) tool was used for the assessment of biases of each included study. RESULTS: Our systematic review included six studies that met the inclusion criteria, all retrospective in design. The rate of histologically proven metastasis of sinonasal SCC to the clinically negative neck is 12.5%. Almost half of the positive cases are pathologically staged as N2 (6.5%). CONCLUSION: Our systematic review provides the rate of sinonasal SCC occult metastasis to the neck so that the surgeons can discuss with patients the risks and possible merits of adding an elective neck management in the surgical plan.

摘要

目的:在治疗临床 N0(cN0)鼻窦鳞状细胞癌(SCC)时,择区性颈部清扫术(END)的作用尚不清楚。在本系统评价中,我们评估了 cN0M0 肿瘤的鼻窦 SCC 隐匿性淋巴结转移的风险,以支持临床决策。

方法:我们在以下三个电子数据库中进行了文献检索:Medline/PubMed、ScienceDirect 和 Google Scholar。根据系统评价和荟萃分析的首选报告项目(PRISMA)声明,评估了文章的纳入标准。两名独立作者提取了数据。使用非随机研究的方法学项目(MINORS)工具评估了每项纳入研究的偏倚。

结果:我们的系统评价包括符合纳入标准的 6 项研究,均为回顾性设计。经组织学证实的鼻窦 SCC 向临床阴性颈部转移的发生率为 12.5%。几乎一半的阳性病例病理分期为 N2(6.5%)。

结论:我们的系统评价提供了鼻窦 SCC 隐匿性颈部转移的发生率,以便外科医生可以与患者讨论在手术计划中添加选择性颈部管理的风险和可能的益处。

相似文献

[1]
What is the rate of occult nodal metastasis in squamous cell carcinomas of the sinonasal tract? A systematic review.

Eur Arch Otorhinolaryngol. 2024-7

[2]
Prophylactic dissection of level V in primary mucosal SCC in the clinically N positive neck: A systematic review.

Laryngoscope. 2017-9

[3]
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.

Head Neck. 2015-9

[4]
Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta-analysis.

Laryngoscope. 2019-8

[5]
Management of contralateral N0 neck in pyriform sinus carcinoma.

Laryngoscope. 2006-7

[6]
Lymph node metastasis in t4 maxillary sinus squamous cell carcinoma: incidence and treatment outcome.

Ann Surg Oncol. 2014-5

[7]
When should elective neck dissection be performed in maxillary gingival and alveolar squamous cell carcinoma with a cN0 neck? A systematic review.

Int J Oral Maxillofac Surg. 2016-11

[8]
Assessment of the Rate of Skip Metastasis to Neck Level IV in Patients With Clinically Node-Negative Neck Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.

JAMA Otolaryngol Head Neck Surg. 2019-6-1

[9]
Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck.

Head Neck. 2020-9

[10]
Elective neck dissection in primary parotid carcinomas: A systematic review and meta-analysis.

J Oral Pathol Med. 2021-2

引用本文的文献

[1]
Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances.

Cancers (Basel). 2024-12-24

本文引用的文献

[1]
Current status of sinonasal cancer survivorship care.

Head Neck. 2023-9

[2]
The role of elective neck dissection in T1 and T2 nasal cavity squamous cell carcinomas.

Eur Arch Otorhinolaryngol. 2023-4

[3]
The contemporary management of cancers of the sinonasal tract in adults.

CA Cancer J Clin. 2023-1

[4]
Surgery for maxillary oral squamous cell carcinoma: the effect of surgical resection margins and elective neck dissection on oncological outcomes.

Int J Oral Maxillofac Surg. 2023-3

[5]
Quality of life in sinonasal tumors: an up-to-date review.

Curr Opin Otolaryngol Head Neck Surg. 2022-2-1

[6]
Twenty-year experience with salvage total laryngectomy: lessons learned.

J Laryngol Otol. 2021-8

[7]
The Role of Elective Neck Treatment in the Management of Sinonasal Carcinomas: A Systematic Review of the Literature and a Meta-Analysis.

Cancers (Basel). 2021-4-13

[8]
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.

BMJ. 2021-3-29

[9]
Elective neck dissection for T3/T4 cN0 sinonasal squamous cell carcinoma.

Head Neck. 2020-12

[10]
Impact of margin status on survival after surgery for sinonasal squamous cell carcinoma.

Int Forum Allergy Rhinol. 2019-8-22

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