Department of Anatomy and Surgical Anatomy, School of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Medical School, University of Nicosia, 2408, Nicosia, Cyprus.
Eur Arch Otorhinolaryngol. 2024 Jul;281(7):3325-3331. doi: 10.1007/s00405-024-08481-8. Epub 2024 Feb 17.
OBJECTIVE: The role of elective neck dissection (END) in the management of clinical N0 (cN0) squamous cell carcinomas (SCC) of the sinonasal tract is unclear. In this systematic review, we evaluate the risk of occult nodal metastasis in sinonasal SCCs with cN0M0 tumors to support clinical decision making. METHODS: A literature search was conducted in the following three electronic databases: Medline/PubMed, ScienceDirect, and Google Scholar. Articles were assessed for eligibility in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Two independent authors extracted the data. The Methodological Items for Non-Randomized Studies (MINORS) tool was used for the assessment of biases of each included study. RESULTS: Our systematic review included six studies that met the inclusion criteria, all retrospective in design. The rate of histologically proven metastasis of sinonasal SCC to the clinically negative neck is 12.5%. Almost half of the positive cases are pathologically staged as N2 (6.5%). CONCLUSION: Our systematic review provides the rate of sinonasal SCC occult metastasis to the neck so that the surgeons can discuss with patients the risks and possible merits of adding an elective neck management in the surgical plan.
目的:在治疗临床 N0(cN0)鼻窦鳞状细胞癌(SCC)时,择区性颈部清扫术(END)的作用尚不清楚。在本系统评价中,我们评估了 cN0M0 肿瘤的鼻窦 SCC 隐匿性淋巴结转移的风险,以支持临床决策。
方法:我们在以下三个电子数据库中进行了文献检索:Medline/PubMed、ScienceDirect 和 Google Scholar。根据系统评价和荟萃分析的首选报告项目(PRISMA)声明,评估了文章的纳入标准。两名独立作者提取了数据。使用非随机研究的方法学项目(MINORS)工具评估了每项纳入研究的偏倚。
结果:我们的系统评价包括符合纳入标准的 6 项研究,均为回顾性设计。经组织学证实的鼻窦 SCC 向临床阴性颈部转移的发生率为 12.5%。几乎一半的阳性病例病理分期为 N2(6.5%)。
结论:我们的系统评价提供了鼻窦 SCC 隐匿性颈部转移的发生率,以便外科医生可以与患者讨论在手术计划中添加选择性颈部管理的风险和可能的益处。
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