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医疗补助扩大对黑色素瘤患者诊断分期的影响:一项回顾性研究。

The Impact of Medicaid Expansion on Stage at Diagnosis of Melanoma Patients: A Retrospective Study.

作者信息

Muddasani Ramya, Wu Helena T, Win Shwe, Amini Arya, Modi Badri, Salgia Ravi, Trisal Vijay, Wang Edward W, Villalona-Calero Miguel Angel, Chan Aaron, Xing Yan

机构信息

City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

Data Science Institute, The University of Chicago, Chicago, IL 60637, USA.

出版信息

Cancers (Basel). 2024 Dec 28;17(1):61. doi: 10.3390/cancers17010061.

Abstract

BACKGROUND

This study addresses the lack of research on Medicaid expansion's impact on melanoma staging, treatment utilization, and outcomes by evaluating its effects under the Affordable Care Act (ACA), particularly focusing on staging at diagnosis, treatment use, and 3-year mortality outcomes. The objective is to determine whether Medicaid expansion led to earlier melanoma diagnosis and improved survival rates among non-elderly adults (ages 40-64) by analyzing data from the National Cancer Database (NCDB).

METHODS

A total of 12,667 patients, aged 40-64, diagnosed with melanoma from 2010 to 2020 were identified using the NCDB. Difference-in-difference (DID) analysis was performed to analyze tumor staging at presentation between Medicaid expansion states and non-Medicaid expansion states both prior to the expansion and after the expansion.

RESULTS

Of the total patients, 2307 were from the pre-expansion time period residing in Medicaid expansion states (MES) and 1804 in non-Medicaid expansion states. In the post-expansion time period there were 5571 residing in the MES and 2985 in the non-MES. DID analysis revealed a decrease in stage IV melanoma at diagnosis (DID -0.222, < 0.001) between MES and non-MES before and after Medicaid expansion. After expansion, in stage IV, the occurrence of primary surgery was 0.42 in non-MES and 0.44 (difference 0.02); DID analysis was not statistically significant. The use of immunotherapy in MES was significantly higher than in non-MES after expansion ( < 0.001), although DID analysis did not reveal a statistically significant difference. DID analysis showed a statistically significant decrease in 3-year mortality (DID -0.05, = 0.001) between MES and non-MES before and after Medicaid expansion.

CONCLUSIONS

This study revealed the positive impact of the ACA's Medicaid expansion on melanoma stage at presentation, highlighting the importance of public health policies in reducing disparities in mortality rates and early-stage diagnoses. Future research should explore additional barriers to care and evaluate the long-term outcomes of Medicaid expansion to optimize cancer care for vulnerable populations.

摘要

背景

本研究旨在解决关于医疗补助扩大计划对黑色素瘤分期、治疗利用情况及治疗结果影响的研究不足问题,通过评估其在《平价医疗法案》(ACA)下的效果,特别关注诊断时的分期、治疗使用情况以及3年死亡率结果。目的是通过分析国家癌症数据库(NCDB)的数据,确定医疗补助扩大计划是否导致非老年成年人(40 - 64岁)黑色素瘤的早期诊断及生存率提高。

方法

使用NCDB确定了2010年至2020年间共12667例年龄在40 - 64岁、被诊断为黑色素瘤的患者。采用双重差分(DID)分析,以分析医疗补助扩大计划实施前后,医疗补助扩大计划实施州和非医疗补助扩大计划实施州在就诊时的肿瘤分期情况。

结果

在全部患者中,2307例来自医疗补助扩大计划实施前居住在医疗补助扩大计划实施州(MES)的时期,1804例来自非医疗补助扩大计划实施州。在扩大计划实施后的时期,有5571例居住在MES,2985例居住在非MES。DID分析显示,在医疗补助扩大计划实施前后,MES和非MES之间诊断时IV期黑色素瘤有所减少(DID -0.222,<0.001)。扩大计划实施后,在IV期,非MES的初次手术发生率为0.42,MES为0.44(差值0.02);DID分析无统计学意义。扩大计划实施后,MES中免疫疗法的使用显著高于非MES(<0.001),尽管DID分析未显示出统计学上的显著差异。DID分析显示,在医疗补助扩大计划实施前后,MES和非MES之间3年死亡率有统计学意义的下降(DID -0.05,=0.001)。

结论

本研究揭示了ACA的医疗补助扩大计划对就诊时黑色素瘤分期的积极影响,突出了公共卫生政策在降低死亡率差异和早期诊断方面的重要性。未来的研究应探索更多的护理障碍,并评估医疗补助扩大计划的长期结果,以优化对弱势群体的癌症护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a50/11719024/54f3dfc0741d/cancers-17-00061-g001.jpg

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