Liu Jie, Yan Lian, Deng Huangsen, Qin Mingxin, Chen Mingsheng
Department of Biomedical Engineering, Army Medical University, The Third Military Medical University, Chongqing 400038, China.
Department of Medical Engineering, Dongnan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 363000, China.
Sensors (Basel). 2024 Dec 30;25(1):157. doi: 10.3390/s25010157.
Magnetic induction phase shift is a promising technology for the detection of cerebral hemorrhage, owing to its nonradioactive, noninvasive, and real-time detection properties. To enhance the detection sensitivity and linearity, a zero-flow sensor was proposed. The uniform primary magnetic field and its counteraction were achieved. Phase-change responses to solutions of varying conductivities and rabbits with cerebral hemorrhage were investigated and compared with traditional sensors. The sensitivities in detecting solutions with different conductivities were 1.84, 1.39, and 1.22 times higher than those for a low-pass birdcage coil, planar gradiometer, and Bx-sensor, respectively. The results for rabbits with cerebral hemorrhage showed that the sensitivities increased by 1.17, 1.67, and 6.3 times compared with a low-pass birdcage coil, symmetric cancelation-type sensor, and single co-axial coil, respectively. This sensor could accurately detect three stages in the pathological process. Blood loss of 1 mL meant that the compensatory mechanism of cerebrospinal fluid began to fail, and 1.4 mL of blood loss meant that the compensatory mechanism failed completely. The adjusted R-squared value of the first-order linear fit was above 0.98 in both physical and animal experiments, indicating that high detection linearity was achieved. The proposed sensor provides a more accurate method for cerebral hemorrhage detection and facilitates the practical application of magnetic induction phase shift in pre-hospital and bedside real-time detection.
磁感应相移是一种很有前景的脑出血检测技术，因其具有非放射性、非侵入性和实时检测特性。为提高检测灵敏度和线性度，提出了一种零流量传感器。实现了均匀的一次磁场及其抵消。研究了对不同电导率溶液和脑出血兔子的相变响应，并与传统传感器进行了比较。在检测不同电导率溶液时，其灵敏度分别比低通鸟笼线圈、平面梯度计和Bx传感器高1.84倍、1.39倍和1.22倍。对脑出血兔子的检测结果表明，与低通鸟笼线圈、对称抵消型传感器和单同轴线圈相比，其灵敏度分别提高了1.17倍、1.67倍和6.3倍。该传感器能够准确检测病理过程中的三个阶段。失血1 mL意味着脑脊液的代偿机制开始失效，失血1.4 mL意味着代偿机制完全失效。在物理实验和动物实验中，一阶线性拟合的调整R平方值均高于0.98，表明实现了高检测线性度。所提出的传感器为脑出血检测提供了一种更准确的方法，并促进了磁感应相移在院前和床边实时检测中的实际应用。
