Orhan Ozhan, Gokdemir Gul Sahika
Department of Pediatrics, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey.
Department of Physiology, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey.
J Clin Med. 2024 Dec 26;14(1):61. doi: 10.3390/jcm14010061.
Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. : A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. : C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children ( < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.
脑瘫（CP）是一种由脑损伤导致的运动障碍，在儿童中很常见。铁对身体的基本功能至关重要。铁代谢紊乱和炎症会导致脑瘫中出现的神经并发症。本研究的目的是确定脑瘫患儿炎症标志物与铁代谢之间的关联和相关性。：本研究回顾性纳入了181名被诊断为脑瘫的儿童和111名发育正常的儿童。评估了人口统计学数据、血液参数、C反应蛋白、铁、总铁结合力和炎症标志物。：发现脑瘫患儿的C反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）和全身免疫炎症指数（SII）水平在统计学上显著高于对照组儿童（<0.05）。脑瘫组的铁（Fe）和铁蛋白水平较低，而总铁结合力（TIBC）较高。Spearman相关性分析显示铁、铁蛋白、TIBC与SII之间存在显著相关性。铁缺乏和慢性炎症与脑瘫患者脑瘫的病理生理学相关，因此监测这些患者的铁代谢和炎症标志物很重要。
