Riewruja Kanyakorn, Amarase Chavarin, Osateerakun Phatcharapa, Weerasopone Soarawit, Limpaphayom Noppachart, Honsawek Sittisak
Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Department of Biochemistry, Osteoarthritis and Musculoskeleton Research Unit, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Biomed Rep. 2020 Dec;13(6):63. doi: 10.3892/br.2020.1370. Epub 2020 Oct 16.
The aim of the present study was to investigate the neutrophil-to-lymphocyte ratio (NLR) level in children with cerebral palsy (CP) living at home or the rehabilitation center. The correlation of NLR with different severities of motor impairment was assessed. This was a single-center, cross-sectional, observational study. A total of 80 CP children who were either living at home (n=34) or at the rehabilitation center (n=46) were included. Demographic characteristics, anthropometric parameters and complete blood counts were recorded, and the NLR values were calculated. The severity of motor impairment was evaluated and categorized according to the Gross Motor Functional Classification System (GMFCS) level. The mean age of CP participants was 8.52±1.92 years. The percentage of children with CP who were malnourished (underweight, stunted and wasted) was higher amongst those at the rehabilitation center compared with those living at home. The mean NLR of children with CP in the rehabilitation center was significantly higher compared with the patients living at home (P=0.003). Participants from the rehabilitation center had severe motor impairment (GMFCS levels IV-V) and significantly higher NLR values than those with mild motor impairments (GMFCS levels II-III; P=0.006). However, there were no differences in NLR values in relation to severity of motor impairment in CP children living at home. CP children had some degree of neuroinflammation and systemic inflammation. NLR may be a potential simple inflammatory parameter that may be used to predict the severity of the motor impairment, particularly in CP children living at a rehabilitation center.
本研究的目的是调查居家或在康复中心生活的脑瘫（CP）儿童的中性粒细胞与淋巴细胞比值（NLR）水平。评估了NLR与不同程度运动障碍的相关性。这是一项单中心、横断面观察性研究。共纳入80名CP儿童，其中居家儿童（n = 34），在康复中心儿童（n = 46）。记录人口统计学特征、人体测量参数和全血细胞计数，并计算NLR值。根据粗大运动功能分类系统（GMFCS）水平评估并分类运动障碍的严重程度。CP参与者的平均年龄为8.52±1.92岁。与居家儿童相比，康复中心CP儿童中营养不良（体重不足、发育迟缓、消瘦）儿童的比例更高。康复中心CP儿童的平均NLR显著高于居家患者（P = 0.003）。来自康复中心的参与者存在严重运动障碍（GMFCS水平IV - V），其NLR值显著高于轻度运动障碍者（GMFCS水平II - III；P = 0.006）。然而，居家CP儿童的NLR值在运动障碍严重程度方面没有差异。CP儿童存在一定程度的神经炎症和全身炎症。NLR可能是一个潜在的简单炎症参数，可用于预测运动障碍的严重程度，尤其是在康复中心生活的CP儿童中。
