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生殖器佩吉特病和雀斑样外阴黑色素瘤手术治疗中的延迟切缘控制

Deferred Lateral Margin Control in the Surgical Treatment of Genital Paget's Disease and Lentiginous Vulvar Melanoma.

作者信息

Redondo Pedro

机构信息

Department of Dermatology, University Clinic of Navarra, 28027 Madrid, Spain.

出版信息

J Clin Med. 2024 Dec 26;14(1):69. doi: 10.3390/jcm14010069.

Abstract

Some skin tumors can extend beyond their clinical appearance. This presents an additional challenge, especially when the affected area is the genital region, which is more difficult for both the patient and the physician to access and monitor due to its location and anatomical characteristics. The treatment of these lesions is complex, and literature postulates Mohs surgery as the best therapeutic option. We describe our experience in two patients with the resection of vulvar lentiginous melanoma and genital extramammary Paget's disease, using a method of deferred lateral margin control in the surgical treatment. The "spaghetti technique"(ST) initially removing a small strip from all lateral margins of the lesion, which is then closed directly while awaiting the paraffin histological result. In a second stage, the tumors within those margins are removed, and immediate reconstruction is performed. The final oncological and functional result was satisfactory, with no notable side effects. This method is suited for large, poorly defined superficial tumors in the genital, perineal, and perianal regions, where a frozen section study would be slow and burdensome for the patient and surgeon. The ST preserves healthy tissue and can be performed by any surgeon and pathologist without additional training, and is more comfortable for patients, avoiding prolonged open wounds during multiple steps of tumor excision.

摘要

一些皮肤肿瘤的范围可能超出其临床表现。这带来了额外的挑战,尤其是当患区为生殖器区域时,由于其位置和解剖特征,患者和医生对该区域进行检查和监测都更加困难。这些病变的治疗很复杂,文献认为莫氏手术是最佳治疗选择。我们描述了两例患者的治疗经验,分别是外阴雀斑样黑色素瘤切除术和生殖器外佩吉特病切除术,采用了手术治疗中延迟控制侧切缘的方法。“意大利面条技术”(ST)最初从病变的所有侧切缘切除一小条组织,然后直接缝合,同时等待石蜡组织学结果。在第二阶段,切除这些切缘内的肿瘤,并立即进行重建。最终的肿瘤学和功能结果令人满意,且无明显副作用。该方法适用于生殖器、会阴和肛周区域的大型、边界不清的浅表肿瘤,在这些区域进行冰冻切片检查对患者和外科医生来说既耗时又麻烦。ST能保留健康组织,任何外科医生和病理学家无需额外培训即可操作,对患者来说更舒适,避免了在肿瘤切除的多个步骤中长时间的开放伤口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5641/11722479/85c9e733c88b/jcm-14-00069-g001.jpg

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