Lv Shen, He Zhi-Peng, Liu Guang-Mao, Hu Sheng-Shou
Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Guangdong Province, China.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Comput Methods Biomech Biomed Engin. 2025 Jan 11:1-12. doi: 10.1080/10255842.2024.2448299.
Impeller radial gap is one of important parts within a blood pump, which may affect the hemodynamics and hemocompatibility. In this study, computational fluid dynamics method was performed to evaluate the impact of radial gap sizes. The volume of scalar shear stress decreased with radial gap sizes increasing. On the contrary, the residence time increased with radial gap sizes increasing, especially in the bottom gap. The hemolysis index and platelet activation status at three flow rates decreased with the increase of radial gap sizes. Compared with the hemolysis index when the radial gap size was 0.6 mm, the hemolysis index for the radial gap of 1.0 mm decreased by 27.6%, 25.4% and 21.1% from low flow rate to high flow rate, respectively. Similarly, the platelet activation status for the radial gap of 1.0 mm decreased by 13.0%, 11.5% and 9.1%, respectively. As a novelty, this study revealed that radial gap sizes can significantly influence the blood pump hemocompatibility, especially at low flow rate. In addition, the hemolysis performance can be more affected by radial gaps than that on thrombosis risk.
叶轮径向间隙是血泵内部的重要部件之一，它可能会影响血液动力学和血液相容性。在本研究中，采用计算流体动力学方法来评估径向间隙尺寸的影响。标量剪切应力的体积随径向间隙尺寸的增加而减小。相反，停留时间随径向间隙尺寸的增加而增加，尤其是在底部间隙。在三种流速下，溶血指数和血小板活化状态随径向间隙尺寸的增加而降低。与径向间隙尺寸为0.6毫米时的溶血指数相比，径向间隙为1.0毫米时的溶血指数在低流速到高流速下分别降低了27.6%、25.4%和21.1%。同样，径向间隙为1.0毫米时的血小板活化状态分别降低了13.0%、11.5%和9.1%。作为一项新发现，本研究表明径向间隙尺寸可显著影响血泵的血液相容性，尤其是在低流速时。此外，溶血性能受径向间隙的影响比血栓形成风险更大。
