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一项关于65锌在某些啮齿动物富含锌组织中的命运的放射自显影研究。

An autoradiographic study on the fate of 65Zn in zinc-rich tissues in some rodents.

作者信息

Dencker L, Tjälve H

出版信息

Med Biol. 1979;57(6):391-7.

PMID:397978
Abstract

Whole-body autoradiography of 65Zn, administered as 65ZnCl2, in mice showed a high initial radioactivity in several parenchymatous organs. Some other tissues showed a rather slow accumulation and a pronounced retention of 65Zn. This applied to the pancreatic islets, which showed the highest soft-tissue radioactivity at most survival intervals and in which 65Zn was detected still 60 days after a single dose. 65Zn was also retained in the hippocampus of the brain, the dorsolateral prostate, Paneth cells in the intestine, the bone and the hair. A few guinea-pigs and rabbits were studied. In the guinea-pigs, there was no specific labelling of the pancreatic islets. The rabbits showed the highest soft-tissue radioactivity in the mandibular salivary gland. Most tissues which retained a high level of 65 Zn have previously been reported as containing high levels of endogenous zinc. The results of the present study indicate that there is a slow zinc-turnover in these tissues.

摘要

以氯化锌((^{65}ZnCl_2))形式给予小鼠的(^{65}Zn)全身放射自显影显示,几个实质器官最初具有高放射性。其他一些组织显示(^{65}Zn)的积累相当缓慢且滞留明显。这适用于胰岛,在大多数存活时间间隔内,胰岛显示出最高的软组织放射性,并且在单次给药后60天仍能检测到(^{65}Zn)。(^{65}Zn)也保留在脑的海马体、背外侧前列腺、肠中的潘氏细胞、骨骼和毛发中。研究了几只豚鼠和兔子。在豚鼠中,胰岛没有特异性标记。兔子的下颌唾液腺显示出最高的软组织放射性。大多数保留高水平(^{65}Zn)的组织先前已被报道含有高水平的内源性锌。本研究结果表明这些组织中锌的周转缓慢。

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