[螯合剂诱导的实验性糖尿病中胰岛的锌含量]
[Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].
作者信息
Bavel'skiĭ Z E, Zaviazkina T V, Moiseev Iu S, Medvedev V I
出版信息
Patol Fiziol Eksp Ter. 1992 May-Jun(3):29-32.
The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs. It is concluded that diabetogenic chelating agents are capable of producing irreversible diabetogenic affection in those beta-cells which contain a critical concentration of reactant zinc.
采用原子吸收分光光度法测定了兔、小鼠、大鼠和豚鼠微切除胰岛中的锌含量。结果发现兔的锌含量最高，且用螯合剂很容易在兔身上诱发糖尿病。注射双硫腙或8-（对甲苯磺酰胺基）喹啉未能在小鼠、大鼠和豚鼠中诱发糖尿病。结论是，致糖尿病螯合剂能够在那些含有临界浓度反应性锌的β细胞中产生不可逆的致糖尿病作用。
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