Dura Mustafa Cengiz, Aktürk Hilal, Aslan Özgür, Gürsoy Berk, Ekin Murat, Yaşar Levent
Department of Gynecology and Obstetrics Bakırköy Dr. Sadi Konuk Training and Research Hospital University of Health Sciences Istanbul Turkey.
Department of Gynecology and Obstetrics Kahta State Hospital Adıyaman Turkey.
Eur J Obstet Gynecol Reprod Biol. 2025 Mar;306:69-74. doi: 10.1016/j.ejogrb.2025.01.006. Epub 2025 Jan 6.
This study aims to investigate the relationship between HPV-associated LSIL and HSIL lesions and overactive bladder (OAB) symptoms in postmenopausal women, highlighting the role of severe histopathological lesions.
A retrospective analysis was conducted on postmenopausal women aged 40-65 years who presented at Istanbul Bakırköy Sadi Konuk Training and Research Hospital between January 2021 and March 2023. The study included HPV-positive patients with low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL), as well as HPV-negative controls. OAB symptoms were assessed using the UDI-6, IIQ-7, and OAB-V8 questionnaires. Statistical comparisons were made between HPV-positive and HPV-negative groups, as well as between LSIL and HSIL subgroups.
No significant differences were observed in UDI-6, IIQ-7, and OAB-V8 scores between HPV-positive and HPV-negative patients. However, HSIL patients exhibited significantly higher scores on these questionnaires compared to LSIL patients (p < 0.01), indicating a greater severity of OAB symptoms. Additionally, there was a significant positive correlation between questionnaire scores and variables such as age, gravida, parity, and menopause duration.
HSIL in HPV-positive women is associated with increased severity of OAB symptoms, suggesting a role for HPV-induced inflammation in OAB pathogenesis.
本研究旨在调查绝经后女性中与HPV相关的低度鳞状上皮内病变（LSIL）和高度鳞状上皮内病变（HSIL）与膀胱过度活动症（OAB）症状之间的关系，强调严重组织病理学病变的作用。
对2021年1月至2023年3月期间在伊斯坦布尔巴克尔柯伊萨迪·科努克培训与研究医院就诊的40 - 65岁绝经后女性进行回顾性分析。该研究纳入了HPV阳性的低度鳞状上皮内病变（LSIL）和高度鳞状上皮内病变（HSIL）患者，以及HPV阴性对照。使用UDI - 6、IIQ - 7和OAB - V8问卷评估OAB症状。对HPV阳性和HPV阴性组以及LSIL和HSIL亚组进行统计学比较。
HPV阳性和HPV阴性患者在UDI - 6、IIQ - 7和OAB - V8评分上未观察到显著差异。然而，与LSIL患者相比，HSIL患者在这些问卷上的得分显著更高（p < 0.01），表明OAB症状更严重。此外，问卷得分与年龄、妊娠次数、产次和绝经持续时间等变量之间存在显著正相关。
HPV阳性女性中的HSIL与OAB症状严重程度增加有关，提示HPV诱导的炎症在OAB发病机制中起作用。
