Platelets welcome a new protein disulfide isomerase family member.
作者信息
Flaumenhaft Robert
机构信息
Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Thromb Haemost. 2025 Jan;23(1):36-38. doi: 10.1016/j.jtha.2024.10.006.
Abstract
摘要
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Platelets welcome a new protein disulfide isomerase family member.血小板迎来了一个新的蛋白质二硫键异构酶家族成员。
J Thromb Haemost. 2025 Jan;23(1):36-38. doi: 10.1016/j.jtha.2024.10.006.
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Protein disulfide isomerase activity is released by activated platelets.蛋白质二硫键异构酶活性由活化血小板释放。
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The b' domain of protein disulfide isomerase cooperates with the a and a' domains to functionally interact with platelets.蛋白质二硫键异构酶的 b' 结构域与 a 结构域和 a' 结构域协同作用，与血小板发生功能相互作用。
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Catalysis of disulfide isomerization in thrombospondin 1 by protein disulfide isomerase.蛋白质二硫键异构酶对血小板反应蛋白1中二硫键异构化的催化作用。
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Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease.蛋白质二硫键异构酶抑制在血栓性疾病中的治疗意义。
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Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: a member of a novel protein family related to protein disulfide-isomerase.嗜热栖热菌蛋白质二硫键氧化还原酶的功能特性：与蛋白质二硫键异构酶相关的新型蛋白质家族成员
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Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity.蛋白质二硫键异构酶是硫氧还蛋白还原酶的底物，具有硫氧还蛋白样活性。
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ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.ERp27是一种新的位于内质网的非催化性人蛋白二硫键异构酶家族成员，它与ERp57相互作用。
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本文引用的文献
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A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation.硫氧还蛋白相关跨膜蛋白TMX4在血小板活化和血栓形成中的新作用。
J Thromb Haemost. 2025 Jan;23(1):277-292. doi: 10.1016/j.jtha.2024.09.007. Epub 2024 Sep 20.
2
Targeting cargo to an unconventional secretory system within megakaryocytes allows the release of transgenic proteins from platelets.将 cargo 靶向到巨核细胞内的非常规分泌系统可使转基因蛋白从血小板中释放。
J Thromb Haemost. 2024 Nov;22(11):3235-3248. doi: 10.1016/j.jtha.2024.07.021. Epub 2024 Aug 8.
3
Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis.蛋白质二硫键异构酶切割组氨酸丰富糖蛋白中的变构二硫键以调节血栓形成。
Nat Commun. 2024 Apr 11;15(1):3129. doi: 10.1038/s41467-024-47493-0.
4
Recent advances in vascular thiol isomerases and redox systems in platelet function and thrombosis.血管硫醇异构酶和氧化还原系统在血小板功能和血栓形成中的最新进展。
J Thromb Haemost. 2024 Jul;22(7):1806-1818. doi: 10.1016/j.jtha.2024.03.008. Epub 2024 Mar 20.
5
Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.磺化作用将氧化应激与蛋白质二硫键异构酶氧化酶活性和血栓形成联系起来。
J Thromb Haemost. 2023 Aug;21(8):2137-2150. doi: 10.1016/j.jtha.2023.03.034. Epub 2023 Apr 8.
6
The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential.细胞外 Ero1α/PDI 电子传递系统通过增加谷胱甘肽还原电势来调节血小板功能。
Redox Biol. 2022 Apr;50:102244. doi: 10.1016/j.redox.2022.102244. Epub 2022 Jan 20.
7
A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.内质网蛋白 46（ERp46）在血小板功能和小鼠动脉血栓形成中的新作用。
Blood. 2022 Mar 31;139(13):2050-2065. doi: 10.1182/blood.2021012055.
8
Protein disulfide isomerase-A1 regulates intraplatelet reactive oxygen species-thromboxane A -dependent pathway in human platelets.蛋白二硫键异构酶 A1 调节人血小板内血小板反应性氧物种-血栓素 A2 依赖途径。
J Thromb Haemost. 2022 Jan;20(1):157-169. doi: 10.1111/jth.15539. Epub 2021 Oct 14.
9
Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5.硫氧还蛋白相关跨膜蛋白：TMX1 和小兄弟 TMX2、TMX3、TMX4 和 TMX5。
Cells. 2020 Aug 31;9(9):2000. doi: 10.3390/cells9092000.
10
Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation.巯基异构酶 ERp57 靶向并调节补体激活的凝集素途径。
J Biol Chem. 2019 Mar 29;294(13):4878-4888. doi: 10.1074/jbc.RA118.006792. Epub 2019 Jan 22.
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