Skaarud Kristin J, Gudmundstuen Anne Marte, Pesonen Maiju, Hjermstad Marianne J, Iversen Per Ole, Tjønnfjord Geir E
Department of Haematology, Oslo University Hospital, P.O. Box 4950, Oslo, 0424, Norway.
Lovisenberg Diaconal University College, Oslo, Norway.
Sci Rep. 2025 Jan 11;15(1):1675. doi: 10.1038/s41598-024-84805-2.
Whether the fat-soluble vitamins A, D, E, and K are associated with development of graft-versus-host disease (GvHD) after allogeneic stem cell transplantation, is unclear. We assessed if the levels of these vitamins were associated with development of GvHD during the first year after transplantation using data from a two-armed randomized nutritional intervention trial. Changes in plasma levels during 1-year follow-up were analyzed using a linear mixed model for repeated measurements. Vitamin A, D, E, and K levels changed significantly the first year in both study arms (p < 0.001). Higher levels of vitamin E over time were associated with less acute GvHD grades 3-4 (OR = 0.997, 95% CI: (0.994, 0.999), p = 0.017). No associations were found with vitamin A, D, E and K levels and chronic GvHD. Multivariable analysis adjusted for treatment group, age, pre-transplant vitamin level and risk factors for GvHD did not change the results. Six weeks post-transplantation, higher levels of vitamin E were associated with less acute GvHD grades 3-4, (p = 0.012). In conclusion, we found an association between higher levels of vitamin E over time and less severe acute GvHD. Whether this reflects a causal relationship warrants further study. ClinicalTrials.gov (NCT01181076).
脂溶性维生素A、D、E和K是否与异基因干细胞移植后移植物抗宿主病（GvHD）的发生有关尚不清楚。我们使用双臂随机营养干预试验的数据评估了这些维生素的水平是否与移植后第一年GvHD的发生有关。使用线性混合模型对重复测量数据进行分析，以评估1年随访期间血浆水平的变化。在两个研究组中，维生素A、D、E和K的水平在第一年都有显著变化（p<0.001）。随着时间推移，较高的维生素E水平与较轻的3-4级急性GvHD相关（OR=0.997，95%CI：（0.994，0.999），p=0.017）。未发现维生素A、D、E和K水平与慢性GvHD有关。对治疗组、年龄、移植前维生素水平和GvHD危险因素进行多变量分析后，结果未改变。移植后6周，较高的维生素E水平与较轻的3-4级急性GvHD相关（p=0.012）。总之，我们发现随着时间推移较高的维生素E水平与较轻的急性GvHD之间存在关联。这是否反映因果关系值得进一步研究。ClinicalTrials.gov（NCT01181076）。
