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[小肠细菌过度生长:误解与现实]

[Small intestine bacterial overgrowth: Myths and realities].

作者信息

Guardiola-Arévalo Antonio, Mascort Roca Juanjo, Noguerol Álvarez Mar, Carrillo Muñoz Ricard, Mendive Arbeloa Juan Manuel, Amador Romero Javier

机构信息

Medicina Familiar y Comunitaria, y Aparato Digestivo, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid; Grupo de trabajo de Digestivo de la SoMaMFyC; Grupo de trabajo de Patología digestiva y hepática de la semFYC, España.

Medicina Familiar y Comunitaria, Centro de Atención Primaria Florida Sud, Institut Català de la Salut, Hospitalet de Llobregat, Barcelona; Departament de Ciències Clíniques, Facultat de Medicina, Universitat de Barcelona, Barcelona; Grupo de trabajo de Patología digestiva y hepática de la semFYC, España.

出版信息

Aten Primaria. 2025 Apr;57(4):103201. doi: 10.1016/j.aprim.2024.103201. Epub 2025 Jan 11.

Abstract

The small intestine bacterial overgrowth (SIBO) is a clinical disorder resulting from colonization of the small intestine by an excessive number of microorganisms or by unusual microorganisms. When they are methane producers it is called intestinal methanogen overgroth (IMO). Known risk factors are congenital or acquired anatomical alterations, motility alterations, some systemic and autoimmune diseases, those that cause alterations in biliopancreatic secretions, hypochlorhydria and some drugs. It causes abdominal pain and distension, bloating, diarrhea, nausea, and weight loss, which can occur in different diseases or with intestinal malabsorption. In IMO there may be constipation. Suggestive analytical data may be iron deficiency, anemia, deficiency of fat-soluble vitamins or B. The breath test with detection of exhaled H is the most accessible technique, but requires rigorous performance and interpretation. The central treatment is oral antibiotics, rifaximin of choice, but they are empirical and should only be prescribed in the event of high clinical suspicion.

摘要

小肠细菌过度生长(SIBO)是一种临床病症,由小肠被过量微生物或异常微生物定植所致。当这些微生物产生甲烷时,称为肠道产甲烷菌过度生长(IMO)。已知的风险因素包括先天性或后天性解剖结构改变、动力改变、一些全身性和自身免疫性疾病、导致胆胰分泌物改变的疾病、胃酸过少以及某些药物。它会引起腹痛、腹胀、腹部膨胀、腹泻、恶心和体重减轻,这些症状可能出现在不同疾病中或伴有肠道吸收不良。在IMO中可能会出现便秘。提示性的分析数据可能是缺铁、贫血、脂溶性维生素或维生素B缺乏。检测呼出氢气的呼气试验是最容易操作的技术,但需要严格执行和解读。主要治疗方法是口服抗生素,首选利福昔明,但这些治疗是经验性的,仅在临床高度怀疑时才应开具处方。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23bb/11770485/36b80bf78d4e/gr1.jpg

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