Jacob Connor C, Eaton Ryan, Ward Jacob, Sette Katelyn, Wilson Seth, Weber Matthieu D, Duru Olivia, Keister Alexander, Harrigan Markus E, Grossbach Andrew J, Viljoen Stephanus
College of Medicine, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, United States.
Department of Neurosurgery, The Ohio State University, 410 W 10th Ave, Columbus, OH 43210, United States.
Clin Neurol Neurosurg. 2025 Feb;249:108731. doi: 10.1016/j.clineuro.2025.108731. Epub 2025 Jan 6.
Lumbar degenerative spinal disease is a common, major cause of pain and disability. Titanium and polyetheretherketone (PEEK) are popular materials for interbody implants although evidence is mixed on which material is superior in terms of fusion and subsidence. The purpose of this study was to evaluate the clinical outcome of 3D printed titanium (3DPT) cages in patients undergoing TLIFs, as well as complication profiles based on widely used outcome metrics and reoperation events.
A retrospective review was conducted for patients receiving 1- or 2-level TLIF at an academic medical center between January 2018 and May 2022. Patients were divided into two cohorts according to the material of interbody cage(s), either 3DPT banana or titanium-coated PEEK bullet. Radiographs, patient-reported outcome measures (PROMs), and complications were analyzed and compared. All included patients had radiographic and clinical follow-up of at least one year.
200 patients with 277 interbody cage-implanted levels were included. Patients received either 3DPT (n = 140) or PEEK (n = 60) interbody cages with 202 and 75 instrumented vertebral levels per cohort, respectively. At one year, the 3DPT cohort demonstrated a higher fusion rate of 93.3 % compared to the PEEK cohort's fusion rate of 73.2 % (p < 0.0001). Subsidence rates were 6.0 % and 25.0 % for the 3DPT and PEEK groups, respectively (p < 0.0001).
While 3DPT and PEEK interbody cages demonstrated few adverse events at short- and long-term follow-up, 3DPT exhibited a higher rate of fusion and lower rate of subsidence at one year.
腰椎退行性脊柱疾病是疼痛和残疾的常见主要原因。钛和聚醚醚酮(PEEK)是椎间融合器常用的材料,尽管关于哪种材料在融合和下沉方面更具优势的证据并不一致。本研究的目的是评估接受经椎间孔腰椎椎体间融合术(TLIF)的患者使用3D打印钛(3DPT)椎间融合器的临床结果,以及基于广泛使用的疗效指标和再次手术事件的并发症情况。
对2018年1月至2022年5月在一家学术医疗中心接受单节段或双节段TLIF的患者进行回顾性研究。根据椎间融合器的材料将患者分为两个队列,即3DPT香蕉形或钛涂层PEEK子弹形。对X线片、患者报告的结局指标(PROMs)和并发症进行分析和比较。所有纳入患者均接受了至少一年的影像学和临床随访。
纳入200例植入277个椎间融合器节段的患者。患者分别接受3DPT(n = 140)或PEEK(n = 60)椎间融合器,每组分别有202个和75个器械固定的椎体节段。一年时,3DPT队列的融合率为93.3%,高于PEEK队列的73.2%(p < 0.0001)。3DPT组和PEEK组的下沉率分别为6.0%和25.0%(p < 0.0001)。
虽然3DPT和PEEK椎间融合器在短期和长期随访中不良事件较少,但3DPT在一年时表现出更高的融合率和更低的下沉率。