Han Feng, Liu Yiqun, Wang Qin, Huang Zhenwu
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China.
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Public Nutrition and Health, Beijing, 100050, China.
J Nutr. 2025 Aug;155(8):2508-2518. doi: 10.1016/j.tjnut.2025.01.008. Epub 2025 Jan 10.
The plasma selenoprotein P (SELENOP) concentration leveling out was thought to represent saturation of the functional selenium body pool and an appropriate supply of selenium to all tissues, indicating that the necessary amount of selenium had been supplied. Based on the selenium intake when SELENOP reaches saturation, the estimated average requirement of selenium was set as 50 μg/d, and the recommended nutrient intake was 60 μg/d for Chinese general population. According to a recent study, "lactating Chinese women with the optimal daily selenium intake" was defined, and the adequate intake of 0‒6-mo-old infants was set as 15 μg/d, whereas 20 μg/d was calculated for 7‒12 mo old infants. Considering the negative health effects of intake of excessive nutrient levels of selenium, we recommend reducing the tolerable upper intake level (UL) for adults from 400 to 255 μg/d based on the results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The SELECT trial is a key basis for setting selenium's UL. It has a large sample size and long-term design. It rigorously measures selenium intake and monitors multiple health endpoints precisely. Also, with proper control groups, it effectively determines the threshold of adverse effects, enhancing the reliability of UL determination.
血浆硒蛋白P（SELENOP）浓度趋于平稳被认为代表了功能性硒体内储备的饱和以及向所有组织的适当硒供应，表明已提供了必要量的硒。根据SELENOP达到饱和时的硒摄入量，中国普通人群的硒估计平均需求量设定为50μg/d，推荐营养素摄入量为60μg/d。根据最近的一项研究，定义了“每日硒摄入量最佳的中国哺乳期妇女”，0至6个月大婴儿的适宜摄入量设定为15μg/d，而7至12个月大婴儿的适宜摄入量经计算为20μg/d。考虑到过量摄入硒对健康的负面影响，我们建议根据硒和维生素E癌症预防试验（SELECT）的结果，将成年人的可耐受最高摄入量（UL）从400μg/d降至255μg/d。SELECT试验是设定硒UL的关键依据。它样本量大、设计长期。它严格测量硒摄入量并精确监测多个健康终点。此外，通过适当的对照组，它有效地确定了不良反应的阈值，提高了UL确定的可靠性。
