Şahin Oruç, Güneş Muzaffer, Dönmez Recep
From the Department of Neurology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye.
Neurosciences (Riyadh). 2025 Jan;30(1):30-35. doi: 10.17712/nsj.2025.1.20240084.
To investigate the potential utility of the C-reactive protein-to-albumin ratio (CAR) and the systemic immune-inflammatory index (SII) as a biomarker in distinguishing between BPPV and acute cerebellar infarction (ACI) due to posterior inferior cerebellar artery (PICA) involvement.
The data of 2545 patients registered in our hospital database between 2017 and 2024 with a diagnosis of vertigo were retrospectively analyzed and 102 patients with benign paroxysmal positional vertigo (BPPV) and 100 patients with ACI were included in the study. Mann-Whitney U test, Chi-square test, or Fisher's exact test were used to compare variables between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of the data.
The CAR and SII values were significantly higher in the ACI group compared to the BPPV group (<0.001, <0.001, respectively). The areas under the ROC curve (AUC) were as follows: CAR=0.768 (95% CI, 0.705-0.832), white blood cell count (WBC)=0.735 (95% CI, 0.667-0.802), monocytes=0.622 (95% CI, 0.544-0.699), red cell distribution width-standard deviation (RDW-SD)=0.600 (95% CI, 0.522-0.678), SII=0.674 (95% CI, 0.599-0.748), and neutrophil-to-lymphocyte ratio (NLR)=0.687 (95% CI, 0.613-0.761).
CAR and SII could be useful biomarkers to differentiate between ACI and BPPV in vertigo patients, but further validation is needed in larger studies.
探讨C反应蛋白与白蛋白比值（CAR）及全身免疫炎症指数（SII）作为生物标志物在鉴别良性阵发性位置性眩晕（BPPV）与因小脑后下动脉（PICA）受累导致的急性小脑梗死（ACI）中的潜在效用。
回顾性分析2017年至2024年在我院数据库中登记的2545例诊断为眩晕的患者数据，研究纳入102例良性阵发性位置性眩晕（BPPV）患者和100例急性小脑梗死（ACI）患者。采用曼-惠特尼U检验、卡方检验或费舍尔精确检验比较两组间的变量。进行受试者工作特征（ROC）曲线分析以研究数据的预测价值。
ACI组的CAR和SII值显著高于BPPV组（分别为<0.001，<0.001）。ROC曲线下面积（AUC）如下：CAR = 0.768（95%可信区间，0.705 - 0.832），白细胞计数（WBC）= 0.735（95%可信区间，0.667 - 0.802），单核细胞 = 0.622（95%可信区间，0.544 - 0.699），红细胞分布宽度标准差（RDW-SD）= 0.600（95%可信区间，0.522 - 0.678），SII = 0.674（95%可信区间，0.599 - 0.748），中性粒细胞与淋巴细胞比值（NLR）= 0.687（95%可信区间，0.613 - 0.761）。
CAR和SII可能是眩晕患者中鉴别ACI和BPPV的有用生物标志物，但需要在更大规模研究中进一步验证。
