Tekeşin Aysel, Tunç Abdulkadir
Clinic of Neurology, Health Sciences University, İstanbul Training and Research Hospital, İstanbul, Turkey.
Clinic of Neurology, Sakarya University, Sakarya Training and Research Hospital, Sakarya, Turkey.
Ideggyogy Sz. 2018 Nov 30;71(11-12):411-416. doi: 10.18071/isz.71.0411.
Objective - Benign paroxysmal positional vertigo (BPPV) is the most common cause of recurrent vertigo. Inflammation is a hypothetic etiological factor in BPPV. The aim of this study was to evaluate inflammatory biomarker levels in BPPV patients and compare these with the healthy subjects. Materials and methods - This prospective case-control study was conducted with 114 newly diagnosed BPPV patients and age- and sex- matched 83 healthy subjects. The laboratory investigations included serum hemogram, full biochemistry profiles, vitamin levels, thyroid hormone profiles, high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte to HDL-cholesterol ratio (MHR) values were calculated and compared between the patients and healthy subjects. Results - The mean age was 39.1 ± 12.4 years for patients, and 37.0 ± 11.9 for controls. Vitamin B12, hematocrit (Hct), creatinine, urea, and fT4 values, lymphocyte, total bilirubin, direct bilirubin and indirect bilirubin levels were significantly lower in BPPV patients (p ˂ 0.05), while HDL, SGOT, and ESR values were significantly higher. In the BPPV patients the mean NLR, PLR, and mean platelet volume (MPV) values were significantly higher than in the control subjects. Neutrophil, platelet, monocyte, MHR, and CRP values were similar in both groups (p ˃ 0.05). Conclusion - Our result suggests that NLR, PLR, MPV, ESR, and bilirubin levels should be taken into account as potential biomarkers of BPPV. As they are inexpensive parameters and widely available, they can be used in clinical practice for prediction of BPPV. However, further large-scale studies are required to confirm this relationship.
目的——良性阵发性位置性眩晕（BPPV）是复发性眩晕最常见的病因。炎症是BPPV的一个假设病因。本研究的目的是评估BPPV患者的炎症生物标志物水平，并将其与健康受试者进行比较。
材料与方法——本前瞻性病例对照研究纳入了114例新诊断的BPPV患者以及83例年龄和性别匹配的健康受试者。实验室检查包括血清血常规、全生化指标、维生素水平、甲状腺激素指标、高敏C反应蛋白（hsCRP）和红细胞沉降率（ESR）。计算患者与健康受试者之间的中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及单核细胞与高密度脂蛋白胆固醇比值（MHR），并进行比较。
结果——患者的平均年龄为39.1±12.4岁，对照组为37.0±11.9岁。BPPV患者的维生素B12、血细胞比容（Hct）、肌酐、尿素和游离甲状腺素（fT4）值、淋巴细胞、总胆红素、直接胆红素和间接胆红素水平显著较低（p＜0.05），而高密度脂蛋白（HDL）、谷草转氨酶（SGOT）和ESR值显著较高。BPPV患者的平均NLR、PLR和平均血小板体积（MPV）值显著高于对照组。两组的中性粒细胞、血小板、单核细胞、MHR和CRP值相似（p＞0.05）。
结论——我们的结果表明，NLR、PLR、MPV、ESR和胆红素水平应被视为BPPV的潜在生物标志物。由于它们是廉价且广泛可用的参数，可用于临床实践中预测BPPV。然而，需要进一步的大规模研究来证实这种关系。
