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神经学和性激素对哮喘影响的共同靶点研究的最新进展

Recent advances in research on common targets of neurological and sex hormonal influences on asthma.

作者信息

Zhou Wenting, Chen Huan, Chen Xinyu, Gao Jing, Ji Wenting

机构信息

China Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

出版信息

Clin Transl Allergy. 2025 Jan;15(1):e70022. doi: 10.1002/clt2.70022.

Abstract

BACKGROUND

Asthma is currently one of the most common of respiratory diseases, severely affecting the lives of patients. With the in-depth study of the role of the nervous system and sex hormones on the development of asthma, it has been found that the nervous system and sex hormones are related to each other in the pathway of asthma.

OBJECTIVE

To investigate the effects of sex hormones and the nervous system on the development of asthma.

METHODS

In this review, we searched for a large number of relevant literature to elucidate the unique mechanisms of sex hormones and the nervous system on asthma development, and summarized several common targets in the pathways of sex hormones and the nervous system on asthma.

CONCLUSION

We summarize several common important targets in the pathways of action of sex hormones and the nervous system in asthma, provide new directions and ideas for asthma treatment, and discuss current therapeutic limitations and future possibilities. Finally, the article predicts future applications of several important targets in asthma therapy.

摘要

背景

哮喘是目前最常见的呼吸系统疾病之一,严重影响患者的生活。随着对神经系统和性激素在哮喘发病中作用的深入研究,发现神经系统和性激素在哮喘发病途径中相互关联。

目的

探讨性激素和神经系统对哮喘发病的影响。

方法

在本综述中,我们检索了大量相关文献,以阐明性激素和神经系统对哮喘发病的独特机制,并总结了性激素和神经系统在哮喘发病途径中的几个共同靶点。

结论

我们总结了性激素和神经系统在哮喘作用途径中的几个共同重要靶点,为哮喘治疗提供了新的方向和思路,并讨论了当前治疗的局限性和未来的可能性。最后,本文预测了几个重要靶点在哮喘治疗中的未来应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d53/11725405/9655770c4bc0/CLT2-15-e70022-g005.jpg

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