分层分析下急诊预警护理对急性应激障碍患者CRP、PCT、TNF-α及临床指标的影响

Impact of Emergency Warning Nursing on CRP, PCT, TNF-α and Clinical Indicators in Patients with Acute Stress Disorder under Hierarchical Analysis.

作者信息

Shao Yanxia, Zhou Xiaoping, Liu Han, Li Tianjiao, Wang Yushu, Chen Ya, Huang Xiangcheng, Sun Wei

机构信息

Emergency Department, The Southwest Hospital of AMU, 400038 Chongqing, China.

Rehabilitation Department, The Southwest Hospital of AMU, 400038 Chongqing, China.

出版信息

Actas Esp Psiquiatr. 2025 Jan;53(1):38-48. doi: 10.62641/aep.v53i1.1685.

DOI:10.62641/aep.v53i1.1685

PMID:39801415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11726204/

Abstract

BACKGROUND

In emergency warning nursing, the pre-alert system significantly influences the biochemical markers and clinical outcomes of patients with Acute Stress Disorder. Therefore, this study applies hierarchical analysis to explore the impact of early warning nursing on crucial indicators such as C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and assess their clinical efficacy.

METHODS

The study selected patients with acute stress disorder who were hospitalized in Southwest Hospital of Chongqing from December 2021 to December 2022, and collected data from 250 patients. Through PSM score matching, 170 patients were finally scored and grouped, 85 patients in each group, which were divided into routine group and stratified analysis group. The changes in serum inflammatory markers, psychological resilience, and post-traumatic growth were compared between the two experimental groups on day 1 of admission and after 14 days of intervention.

RESULT

After one day of admission, there was no significant difference in the serum factor levels, psychological resilience, and post-traumatic growth among the participants (p > 0.05). However, after 14 days of intervention, patients in the hierarchical analysis group showed better outcomes in serum inflammatory markers such as C-reactive protein, procalcitonin, tumor necrosis factor-alpha, and interleukin-6 compared to the conventional group (p < 0.05). The hierarchical analysis group had higher psychological resilience scores regarding strength, optimism, and resilience compared to the conventional group (p < 0.05). Furthermore, the hierarchical analysis group showed higher post-traumatic growth scores regarding mental changes, personal strength, appreciation of life, interpersonal relationship, and new possibilities relative to the conventional group (p < 0.05).

CONCLUSION

Analytic Hierarchy Process (AHP)-based emergency warning nursing can help improve the serum inflammatory factor levels, strengthen psychological resilience, and enhance post-traumatic growth levels in patients with Acute Stress Disorder.

摘要

背景

在应急预警护理中，预报警系统对急性应激障碍患者的生化指标和临床结局有显著影响。因此，本研究应用层次分析法探讨预警护理对C反应蛋白（CRP）、降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）等关键指标的影响，并评估其临床疗效。

方法

本研究选取2021年12月至2022年12月在重庆西南医院住院的急性应激障碍患者，收集250例患者的数据。通过倾向得分匹配法（PSM）最终对170例患者进行评分并分组，每组85例，分为常规组和层次分析法组。比较两组实验组入院第1天和干预14天后血清炎症标志物、心理弹性和创伤后成长的变化。

结果

入院1天后，参与者的血清因子水平、心理弹性和创伤后成长无显著差异（p>0.05）。然而，干预14天后，层次分析法组患者的C反应蛋白、降钙素原、肿瘤坏死因子-α和白细胞介素-6等血清炎症标志物水平较常规组更好（p<0.05）。层次分析法组在力量、乐观和心理弹性方面的心理弹性得分高于常规组（p<0.05）。此外，层次分析法组在心理变化、个人力量、生活欣赏、人际关系和新可能性方面的创伤后成长得分高于常规组（p<0.05）。