Patir Muserref Gamze, Guven Emine Seda Guvendag, Albayrak Mehmet, Guven Suleyman
Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Ortahisar, Trabzon, Turkey.
J Med Ultrasound. 2024 Feb 26;32(4):329-333. doi: 10.4103/jmu.jmu_66_23. eCollection 2024 Oct-Dec.
The effect of congenital cardiac malformation on fetal cerebral circulation has not been well known. This study aimed to compare the cerebral blood circulation of fetuses with congenital heart disease (CHD) with healthy fetuses.
This prospective cohort study included 37 pregnant women who presented to the gynecology and obstetrics department of department of Farabi Hospital, Faculty of Medicine, Karadeniz Technical University for anomaly screening in the second trimester. The women were divided into two groups as those with fetuses having CHD and healthy fetuses. Middle cerebral artery (MCA), peak systolic velocity (PSV), pulsatility index (PI), resistivity index (RI), systole/diastole (S/D) ratio, and MCA transverse section diameter (mm) were recorded for each fetus.
The most common CHDs were truncus arteriosus and hypoplastic left heart syndrome. The mean MCA PSV, resistivity index, and MDCA vessel diameter values were statistically significantly higher in the study group compared with fetuses without CHDs. The mean PI and systole/diastole ratio were statistically significantly lower in the study group than in the control group.
This study reported that MCA PSV, RI, and vessel diameter were significantly higher and the S/D ratio and PI were significantly lower in fetuses with CHD compared to the healthy fetuses.
先天性心脏畸形对胎儿脑循环的影响尚不明确。本研究旨在比较先天性心脏病（CHD）胎儿与健康胎儿的脑血液循环情况。
这项前瞻性队列研究纳入了37名在妊娠中期到卡拉代尼兹技术大学医学院法拉比医院妇产科进行异常筛查的孕妇。这些孕妇被分为两组，一组是胎儿患有先天性心脏病的，另一组是健康胎儿的。记录每个胎儿的大脑中动脉（MCA）、收缩期峰值速度（PSV）、搏动指数（PI）、阻力指数（RI）、收缩/舒张（S/D）比值以及MCA横截面积直径（mm）。
最常见的先天性心脏病是永存动脉干和左心发育不全综合征。与无先天性心脏病的胎儿相比，研究组胎儿的平均MCA PSV、阻力指数和MDCA血管直径值在统计学上显著更高。研究组的平均PI和收缩/舒张比值在统计学上显著低于对照组。
本研究报告称，与健康胎儿相比，患有先天性心脏病的胎儿的MCA PSV、RI和血管直径显著更高，而S/D比值和PI显著更低。
