Li Zhidan, Fang Yan, Wu Junlin, Ma Wenxia
Department of Cardiology, The First People's Hospital of Yibin, Yibin, Sichuan, People's Republic of China.
Int J Gen Med. 2025 Jan 7;18:55-63. doi: 10.2147/IJGM.S485492. eCollection 2025.
To investigate the correlation between premature ventricular contraction (PVC) frequency and heart rate (HR) in Chinese adults, with an emphasis on sex-specific differences in clinical characteristics.
This retrospective study analyzed 24-hour Holter monitoring data from 478 inpatients at the First People's Hospital of Yibin between January 2021 and December 2022. The inclusion criteria were age ≥18 years, ≥20 hours of Holter recording, frequent PVCs (≥ 500 PVCs), and complete clinical profiles. Patients were stratified into three groups on the basis of the hourly correlation between PVC counts and HR: fast heart rate-related PVC (F-HR-PVC), slow heart rate-related PVC (S-HR-PVC), and independent heart rate-related PVC (I-HR-PVC). Heart rate variability (HRV) indices were assessed to evaluate autonomic nervous system activity.
Among the 478 patients, 267 were males and 211 were females with a mean age of 65.7±13.0 years. The mean PVC burden was 5.7±7.0%, and the mean left ventricular ejection fraction (LVEF) was 59.1±8.7%. In males, the F-HR-PVC group was most common (45.3%), while in females, the I-HR-PVC group was most prevalent (50.2%). Despite these observed differences, a chi-square test did not reveal statistically significant differences in the distribution of VPC profiles between sexes (P=0.167). Analysis of clinical characteristics and Holter indices across sex groups showed significant differences in males, particularly in age, maximum heart rate, and minimum heart rate (P < 0.05). In females, significant intergroup differences were observed in VPC burden (P < 0.05).
Although no significant sex differences were observed in the correlation between PVC frequency and HR, the study suggests a potential gender influence on VPC characteristics. These findings may inform future research and have implications for the development of sex-specific diagnostic and therapeutic strategies for PVCs.
探讨中国成年人室性早搏（PVC）频率与心率（HR）之间的相关性，重点关注临床特征的性别差异。
这项回顾性研究分析了2021年1月至2022年12月期间宜宾市第一人民医院478例住院患者的24小时动态心电图监测数据。纳入标准为年龄≥18岁、动态心电图记录时间≥20小时、频发室性早搏（≥500次室性早搏）以及完整的临床资料。根据室性早搏计数与心率的每小时相关性，将患者分为三组：快速心率相关室性早搏（F-HR-PVC）、缓慢心率相关室性早搏（S-HR-PVC）和独立心率相关室性早搏（I-HR-PVC）。评估心率变异性（HRV）指标以评价自主神经系统活动。
478例患者中，男性267例，女性211例，平均年龄65.7±13.0岁。平均室性早搏负荷为5.7±7.0%，平均左心室射血分数（LVEF）为59.1±8.7%。在男性中，F-HR-PVC组最为常见（45.3%），而在女性中，I-HR-PVC组最为普遍（50.2%）。尽管存在这些观察到的差异，但卡方检验未显示性别之间室性早搏类型分布的统计学显著差异（P=0.167）。对不同性别组的临床特征和动态心电图指标分析显示，男性存在显著差异，尤其是在年龄、最大心率和最小心率方面（P<0.05）。在女性中，室性早搏负荷存在显著的组间差异（P<0.05）。
尽管在室性早搏频率与心率的相关性方面未观察到显著的性别差异，但该研究表明性别可能对室性早搏特征有影响。这些发现可能为未来的研究提供参考，并对室性早搏的性别特异性诊断和治疗策略的制定具有启示意义。
