Nouza K, Nĕmec M, Matousek V, Sůla K
Folia Biol (Praha). 1979;25(3):143-55.
The first-set and second-set allotransplantation reactions against skin grafts and the primary and secondary proliferative graft-versus-host reactions in the popliteal lymph nodes were compared in both directions in a non-H-2 system (mouse strain combinations C57BL/10ScSnPh (further B10) and B10.C3H(40NX) further 40NX) differing at H-1 plus H-?). While 40NX recipients gave stronger reactions against B10 antigens in the allotransplantation reactions, the situation was reversed in the GVHR, B10 cells reacting more strongly against 40NX antigens. The findings of a dissociation between the mechanisms of allotransplantation reaction adn proliferative GVHR suggest that the genetic determination of the target antigens and the reacting lymphocyte populations are more complex at the minor histocompatibility systems than has been expected.
在一个非H-2系统（小鼠品系组合C57BL/10ScSnPh（进一步简称为B10）和B10.C3H(40NX)，进一步简称为40NX）中，在H-1加H-？位点存在差异，对皮肤移植的初次和二次同种异体移植反应以及腘窝淋巴结中的初次和二次增殖性移植物抗宿主反应进行了双向比较。虽然在同种异体移植反应中，40NX受体对B10抗原的反应更强，但在移植物抗宿主反应中情况则相反，B10细胞对40NX抗原的反应更强。同种异体移植反应和增殖性移植物抗宿主反应机制之间存在解离的研究结果表明，在次要组织相容性系统中，靶抗原和反应淋巴细胞群体的遗传决定比预期的更为复杂。
