El Sherif Ibrahim Mohammed, Haggag Adham Magdy, Abbas Mohamed Hussen, Kamel Walid Y
Department of Anaesthesia, ICU and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Internal Medicine, National Research Centre, Dokki, Egypt.
Indian J Crit Care Med. 2025 Jan;29(1):52-58. doi: 10.5005/jp-journals-10071-24842. Epub 2024 Dec 30.
Hyperglycemia is a serious condition and associated with an increased risk of complications and mortality in both critically ill and non-critically ill people. Improvement in the glycemic level reduces the length of hospital stay, systemic infections and short- and long-term mortality. The aim was to test the effectiveness of insulin degludec vs insulin glargine and regular insulin in controlling blood sugar in patients with critical hyperglycemia.
Using random control trial, the patients were randomly divided into three equal groups-group R, group G and group D. Each group included 30 patients. Group G was managed using regular insulin together with an insulin glargine. Group D was managed using regular insulin together with an insulin degludec. However, group R was managed using only regular insulin.
The incidence of hypoglycemia was statistically more significant in the group of regular insulin than in groups G and group D with a -value 0.0069. There was no statistically significant difference between the three groups regarding the frequency of hypoglycemia.
Ultra-long-acting insulin can effectively control random blood sugar (RBS) with a decrease in the total dose of insulin used. It is recommended that using insulin degludec is a safe and effective alternative to regular insulin for glycemic control in critically ill patients.
El Sherif IM, Haggag AM, Abbas MH, Kamel WY. Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemia. Indian J Crit Care Med 2025;29(1):52-58.
高血糖是一种严重病症，在重症和非重症患者中均与并发症风险及死亡率增加相关。血糖水平的改善可缩短住院时间、降低全身感染以及短期和长期死亡率。本研究旨在测试德谷胰岛素与甘精胰岛素及常规胰岛素相比，在控制严重高血糖患者血糖方面的有效性。
采用随机对照试验，将患者随机分为三组，每组30例，即R组、G组和D组。G组采用常规胰岛素联合甘精胰岛素进行治疗。D组采用常规胰岛素联合德谷胰岛素进行治疗。而R组仅采用常规胰岛素进行治疗。
常规胰岛素组低血糖发生率在统计学上显著高于G组和D组，P值为0.0069。三组在低血糖发生频率方面无统计学显著差异。
超长效胰岛素可有效控制随机血糖（RBS），同时减少胰岛素总用量。建议在重症患者血糖控制中，使用德谷胰岛素是一种安全有效的常规胰岛素替代方案。
El Sherif IM, Haggag AM, Abbas MH, Kamel WY. Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemia. Indian J Crit Care Med 2025;29(1):52 - 58.
