Ohara Tomoya, Iwai Naoto, Oka Kohei, Okabe Kengo, Sakai Hiroaki, Tsuji Toshifumi, Okuda Takashi, Sakagami Junichi, Kagawa Keizo, Doi Toshifumi, Inoue Ken, Dohi Osamu, Yoshida Naohisa, Yamaguchi Kanji, Moriguchi Michihisa, Uchiyama Kazuhiko, Ishikawa Takeshi, Takagi Tomohisa, Konishi Hideyuki, Itoh Yoshito
Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Kyoto, Kansai 620-0056, Japan.
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kansai 602-8566, Japan.
Oncol Lett. 2024 Dec 31;29(3):114. doi: 10.3892/ol.2024.14860. eCollection 2025 Mar.
Cancer cachexia is a complex disorder characterized by skeletal muscle loss, which may influence the prognosis of patients with cancer. The cachexia index (CXI) is a new index for cachexia. The present study aimed to assess whether the CXI determined by bioelectrical impedance analysis (BIA) is valuable for predicting survival in patients with gastrointestinal cancer. A total of 54 patients with gastrointestinal cancer undergoing BIA at the time of diagnosis at Fukuchiyama City Hospital (Kyoto, Japan) were retrospectively recruited. CXI values were calculated as follows: CXI=skeletal muscle index (SMI) × serum albumin concentration/neutrophil-to-lymphocyte ratio. The SMI was measured using BIA values. The patients were classified into low- and high-CXI groups. The median patient age was 72 years and 63.0% of patients were male. A total of 20 patients with colorectal cancer were enrolled, 12 with pancreatic cancer, 11 with gastric cancer, 6 with esophageal cancer, 4 with biliary tract cancer and 1 with liver cancer. The cumulative one-year overall survival (OS) rate was significantly worse in the low-CXI group compared with that in the high-CXI group (58.3 vs. 88.5%; P=0.012). By contrast, the SMI had no significant effect on OS. Thus, CXI values using BIA may predict survival in patients with gastrointestinal cancer.
癌症恶病质是一种以骨骼肌丢失为特征的复杂病症，可能会影响癌症患者的预后。恶病质指数（CXI）是一种新的恶病质指标。本研究旨在评估通过生物电阻抗分析（BIA）测定的CXI对预测胃肠道癌患者的生存率是否有价值。回顾性招募了在日本京都府福知山市医院确诊时接受BIA检查的54例胃肠道癌患者。CXI值的计算方法如下：CXI = 骨骼肌指数（SMI）×血清白蛋白浓度/中性粒细胞与淋巴细胞比值。使用BIA值测量SMI。将患者分为低CXI组和高CXI组。患者的中位年龄为72岁，63.0%为男性。其中共有20例结直肠癌患者、12例胰腺癌患者、11例胃癌患者、6例食管癌患者、4例胆管癌患者和1例肝癌患者。低CXI组的累积一年总生存率（OS）显著低于高CXI组（58.3%对88.5%；P = 0.012）。相比之下，SMI对OS没有显著影响。因此，使用BIA得出的CXI值可能预测胃肠道癌患者的生存率。
