Fard Tina Moghadam, Hosseinzadeh Mehrnaz, Shokri MohammadAli, Almasi-Dooghaee Mostafa, Mirfazeli Fatemeh Sadat
Cellular and Molecular Research Center, Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran.
National Brain Centre Iran University of Medical Sciences Tehran Iran.
Clin Case Rep. 2025 Jan 10;13(1):e70038. doi: 10.1002/ccr3.70038. eCollection 2025 Jan.
Cerebrovascular thrombosis is among the most critical medical conditions, making early diagnosis and management crucial. Although some symptoms of cerebrovascular thrombosis are typical and lead to early diagnosis, they can sometimes present with rare and unusual symptoms, complicating the diagnostic process. Given the morbidity and mortality associated with these events, it is important to be aware of unexpected symptoms to diagnose and manage these patients more accurately and rapidly. We report a 74-year-old female initially misdiagnosed with Alzheimer's because of cognitive decline and disorganized speech. Her symptoms did not improve with Alzheimer's treatment. She was reevaluated by a neurologist, and her cognitive test results were impaired. Her brain MRI revealed a previously undetected left transverse sinus cerebral venous thrombosis with subcortical white matter lesions. The patient was managed acutely with subcutaneous enoxaparin and transitioned to oral rivaroxaban, resulting in significant improvement. This case report aimed to draw attention to the pitfalls of diagnosing dementia-like syndromes in the elderly, advocating for a systematic approach to differential diagnosis. It emphasizes that a collaborative effort between psychiatrists, neurologists, radiologists, and other healthcare members is essential for accurate diagnosis and timely intervention, which can significantly alter the management and outcome for the patient.
脑血管血栓形成是最危急的病症之一,早期诊断和治疗至关重要。虽然脑血管血栓形成的一些症状较为典型,可实现早期诊断,但有时也会出现罕见和不寻常的症状,使诊断过程变得复杂。鉴于这些病症的发病率和死亡率,了解意外症状对于更准确、快速地诊断和治疗这些患者非常重要。我们报告了一名74岁女性,最初因认知能力下降和言语紊乱被误诊为阿尔茨海默病。接受阿尔茨海默病治疗后,她的症状并未改善。一名神经科医生对她进行了重新评估,其认知测试结果显示受损。她的脑部磁共振成像(MRI)显示左侧横窦脑静脉血栓形成,伴有皮质下白质病变,此前未被发现。该患者接受了皮下注射依诺肝素的急性治疗,并过渡到口服利伐沙班,病情显著改善。本病例报告旨在提醒人们注意老年痴呆样综合征诊断中的陷阱,提倡采用系统的鉴别诊断方法。它强调精神科医生、神经科医生、放射科医生和其他医护人员之间的协作对于准确诊断和及时干预至关重要,这可以显著改变患者的治疗和预后。